发明申请
- 专利标题： MINOR GROOVE BINDER (MGB)-OLIGONUCLEOTIDE MIRNA ANTAGONISTS
- 专利标题（中）： 未成年人绑架（MGB） - 寡头魔术师
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申请号： US12953098申请日： 2010-11-23
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公开(公告)号： US20110172289A1公开(公告)日： 2011-07-14
- 发明人: Anastasia Khvorova , Annaleen Vermeulen , Rob Kaiser , Jon Karpilow , Nicolaas M.J. Vermeulen , Walt Mahoney
- 申请人： Anastasia Khvorova , Annaleen Vermeulen , Rob Kaiser , Jon Karpilow , Nicolaas M.J. Vermeulen , Walt Mahoney
- 专利权人： Elitech Holding B.V.,Dharmacon, Inc.
- 当前专利权人： Elitech Holding B.V.,Dharmacon, Inc.
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/04 ; C12N5/00 ; A61P3/10 ; A61P35/00 ; A61P25/28 ; A61P31/12
摘要：
Compositions and methods for inhibiting the actions of non-coding RNAs such as miRNAs and piRNAs are provided. The compositions comprise single or double stranded oligonucleotides conjugated with Minor Groove Binders (“MGBs”). The oligonucleotides can vary in length, can contain nucleotides having one or more modifications, and have regions that are substantially complementary to one or more mature miRNAs or piRNAs.
公开/授权文献
- US09334495B2 Minor groove binder (MGB)-oligonucleotide miRNA antagonists 公开/授权日：2016-05-10
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