发明申请
US20110172415A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP
审中-公开
用循环集团取代的含氮杂环衍生物（NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES WITH CYCLIC GROUP
- 专利标题： NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP
- 专利标题（中）： 用循环集团取代的含氮杂环衍生物（NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES WITH CYCLIC GROUP
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申请号： US13050465申请日： 2011-03-17
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公开(公告)号： US20110172415A1公开(公告)日： 2011-07-14
- 发明人: Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
- 申请人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
- 申请人地址： JP Osaka
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： JP Osaka
- 优先权： JP2006-046740 20060223; JP2006-149750 20060530; JP2006-318360 20061127
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D401/12 ; C07D405/12 ; C07D401/06 ; C07D401/14 ; C07D405/14 ; C07D403/12 ; C07D417/14 ; C07D417/12 ; C07D471/04 ; C07D295/185 ; C07D413/12
摘要：
It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.A compound represented by: wherein Z is N or CR1, A1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R1, R2, Ra, Rb, Rc and Rd are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is —(CR3R4)m-, —CO(CR3R4)n-, —CONR5(CR3R4)n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R3 and R4 are each independently hydrogen, halogen, hydroxy etc., and R5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt, or a solvate thereof.
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