发明申请
US20110189215A1 Vaccine Comprising Protein NMB0964 From Neisseria Meningitidis
有权
疫苗包括脑膜炎奈瑟氏球菌蛋白NMB0964
- 专利标题： Vaccine Comprising Protein NMB0964 From Neisseria Meningitidis
- 专利标题（中）： 疫苗包括脑膜炎奈瑟氏球菌蛋白NMB0964
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申请号： US13062319申请日： 2009-03-06
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公开(公告)号： US20110189215A1公开(公告)日： 2011-08-04
- 发明人: Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants
- 申请人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants
- 优先权： GB0816447.7 20080908
- 国际申请： PCT/EP2009/052689 WO 20090306
- 主分类号： A61K39/095
- IPC分类号： A61K39/095 ; A61K39/00 ; A61P31/04 ; A61P37/04
摘要：
The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
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