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1.发明授权Vaccines against Bordetella pertussis based on LPS glycosyltransferase mutants 有权基于LPS糖基转移酶突变体的针对百日咳杆菌的疫苗公开(公告)号：US09296995B2
公开(公告)日：2016-03-29
申请号：US12593346
申请日：2008-03-25
CPC分类号： C12N9/1048 , A61K39/00 , A61K39/099
摘要： The invention relates to an improved vaccine against pertussis wherein mutants of Bordetella pertussis having a modified LPS molecule or the obtainable LPS molecules are used. These mutants or the obtainable LPS molecules may further be used as an adjuvant.
摘要翻译： 本发明涉及一种针对百日咳疫苗的改良疫苗，其中使用了具有修饰的LPS分子的百日咳博德特氏菌或可获得的LPS分子的突变体。 这些突变体或可获得的LPS分子可进一步用作佐剂。
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2.发明申请VACCINES AGAINST BORDETELLA PERTUSSIS BASED ON LPS GLYCOSYLTRANSFERASE MUTANTS 有权基于LPS GLYCOSYLTRANSFERASE MUTANTS的BORDETELLA PERTUSSIS疫苗公开(公告)号：US20100291153A1
公开(公告)日：2010-11-18
申请号：US12593346
申请日：2008-03-25
IPC分类号： A61K39/10 , C07H21/00 , A61K35/74 , A61K38/45 , A61P31/04 , C12N9/10 , C12N15/63 , C12N1/21 , C07H1/00
CPC分类号： C12N9/1048 , A61K39/00 , A61K39/099
摘要： The invention relates to an improved vaccine against pertussis wherein mutants of Bordetella pertussis having a modified LPS molecule or the obtainable LPS molecules are used. These mutants or the obtainable LPS molecules may further be used as an adjuvant.
摘要翻译： 本发明涉及一种针对百日咳疫苗的改良疫苗，其中使用了具有修饰的LPS分子的百日咳博德特氏菌或可获得的LPS分子的突变体。 这些突变体或可获得的LPS分子可进一步用作佐剂。
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公开(公告)号：US07628995B2
公开(公告)日：2009-12-08
申请号：US10584362
申请日：2004-12-21
IPC分类号： A61K39/095
CPC分类号： C07K16/1217 , A61K35/74 , A61K2039/521 , C07K14/22 , C07K2317/34 , C07K2319/00
摘要： The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
摘要翻译： 本发明公开了一种革兰氏阴性细菌，其中参与LPS转运至外膜的蛋白质的表达在功能上被下调，使得与野生型革兰氏阴性细菌相比，外膜中的LPS水平降低。 Imp和MsbA蛋白的下调可导致这种细菌。 衍生自本发明的革兰氏阴性细菌的外膜囊泡制剂可用于疫苗中以提供针对细菌感染的保护。
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公开(公告)号：US08163295B2
公开(公告)日：2012-04-24
申请号：US13211977
申请日：2011-08-17
IPC分类号： A61K39/095
CPC分类号： C07K16/1217 , A61K35/74 , A61K2039/521 , C07K14/22 , C07K2317/34 , C07K2319/00
摘要： The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
摘要翻译： 本发明公开了一种革兰氏阴性细菌，其中参与LPS转运至外膜的蛋白质的表达在功能上被下调，使得与野生型革兰氏阴性细菌相比，外膜中的LPS水平降低。 Imp和MsbA蛋白的下调可导致这种细菌。 衍生自本发明的革兰氏阴性细菌的外膜囊泡制剂可用于疫苗中以提供针对细菌感染的保护。
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公开(公告)号：US20120039942A1
公开(公告)日：2012-02-16
申请号：US13211977
申请日：2011-08-17
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C12N1/20
CPC分类号： C07K16/1217 , A61K35/74 , A61K2039/521 , C07K14/22 , C07K2317/34 , C07K2319/00
摘要： The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
摘要翻译： 本发明公开了一种革兰氏阴性细菌，其中参与LPS转运至外膜的蛋白质的表达在功能上被下调，使得与野生型革兰氏阴性细菌相比，外膜中的LPS水平降低。 Imp和MsbA蛋白的下调可导致这种细菌。 衍生自本发明的革兰氏阴性细菌的外膜囊泡制剂可用于疫苗中以提供针对细菌感染的保护。
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6.发明授权Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies 失效脑膜炎奈瑟氏球菌抗原多肽，相应的多核苷酸和保护性抗体公开(公告)号：US06994860B1
公开(公告)日：2006-02-07
申请号：US09701271
申请日：1999-05-26
IPC分类号： A61K39/095 , A61K39/00 , C07H21/04 , C07K1/00
CPC分类号： C07K16/1217 , A61K38/00 , A61K39/00 , A61K2039/51 , A61K2039/53 , C07K14/22
摘要： The invention provides Neisseria meningitidis BASB030 polypeptides and polynucleotides encoding BASB030 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are antibodies, diagnostic, prophylactic and therapeutic uses thereof.
摘要翻译： 本发明提供脑膜炎奈瑟氏球菌BASB030多肽和编码BASB030多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了抗体，诊断，预防和治疗用途。
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公开(公告)号：US20130004510A1
公开(公告)日：2013-01-03
申请号：US13583419
申请日：2011-03-11
申请人： Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Nathalie Isabelle Devos , Vincent Weynants
发明人： Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Nathalie Isabelle Devos , Vincent Weynants
IPC分类号： A61K39/02 , C07K14/22 , C12P21/02 , A61P31/04 , C07K14/285 , C07K14/21 , C07K14/205 , C07K14/235 , C07K14/195 , C07K16/12
CPC分类号： A61K39/095 , A61K39/00 , C07K14/195 , C07K14/22 , C07K16/1217 , Y02A50/401 , Y02A50/476 , Y02A50/478
摘要： Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
摘要翻译： 本文提供了用于治疗或预防革兰氏阴性菌菌株感染的组合物和方法。 本文还提供了制备所述组合物的方法。
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公开(公告)号：US08048433B2
公开(公告)日：2011-11-01
申请号：US11722034
申请日：2005-12-16
CPC分类号： A61K39/099 , C07K14/235 , C12N9/18
摘要： The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
摘要翻译： 本发明提供了具有脂质A 3-O-脱酰酶活性的新革兰氏阴性多肽，并能够改变和/或解毒革兰氏阴性LPS。 本发明还提供了革兰氏阴性细菌，革兰氏阴性细菌脂多糖（LPS）和包含LPS的组合物，其被提供或用本发明的3-O-脱酰酶活性处理并且可用于药物和/或兽医 目的，特别是用于制备针对病原性革兰氏阴性的全细胞或无细胞疫苗，例如百日咳杆菌，百日咳博德特氏菌和支气管炎博德特氏菌。
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公开(公告)号：US20110189215A1
公开(公告)日：2011-08-04
申请号：US13062319
申请日：2009-03-06
申请人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants
发明人： Martine Petronella Bos , Jan Poolman , Michiel Stork , Johannes Petrus Maria Tommassen , Vincent Weynants
IPC分类号： A61K39/095 , A61K39/00 , A61P31/04 , A61P37/04
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/575 , C07K14/22 , C12P21/00
摘要： The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bacterial antibodies are generated against said antigen. Methods are also provided to upregulate expression through removal of the zinc repression mechanism of the cell or promoter or through removal of zinc from the culture medium.
摘要翻译： 本发明涉及包含具有上调NMB0964抗原水平的奈瑟氏球菌的免疫原性组合物，使得针对所述抗原产生细菌抗体。 还提供了通过去除细胞或启动子的锌抑制机制或通过从培养基中除去锌来上调表达的方法。
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公开(公告)号：US20080274145A1
公开(公告)日：2008-11-06
申请号：US11722034
申请日：2005-12-16
IPC分类号： A61K39/10 , C12N9/14 , C07K14/00 , C12N15/11 , C12N15/55 , A61P31/04 , C12N15/74 , C07K16/12 , C12N1/21 , C12P19/04
CPC分类号： A61K39/099 , C07K14/235 , C12N9/18
摘要： The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
摘要翻译： 本发明提供了具有脂质A 3-O-脱酰酶活性的新革兰氏阴性多肽，并能够改变和/或解毒革兰氏阴性LPS。 本发明还提供了革兰氏阴性细菌，革兰氏阴性细菌脂多糖（LPS）和包含LPS的组合物，其被提供或用本发明的3-O-脱酰酶活性处理并且可用于药物和/或兽医 目的，特别是用于制备针对病原性革兰氏阴性的全细胞或无细胞疫苗，例如百日咳杆菌，百日咳博德特氏菌和支气管炎博德特氏菌。
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