发明申请
US20110190340A1 BI- AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES
有权
双取代和多环取代的异喹啉和异喹啉衍生物
- 专利标题： BI- AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES
- 专利标题（中）： 双取代和多环取代的异喹啉和异喹啉衍生物
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申请号： US13000202申请日： 2009-06-18
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公开(公告)号： US20110190340A1公开(公告)日： 2011-08-04
- 发明人: Oliver Plettenburg , Katrin Lorenz , Matthias Loehn , Olivier Duclos , Sandrine Biscarrat
- 申请人： Oliver Plettenburg , Katrin Lorenz , Matthias Loehn , Olivier Duclos , Sandrine Biscarrat
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： EP08290607.4 20080624
- 国际申请： PCT/EP2009/004393 WO 20090618
- 主分类号： A61K31/4725
- IPC分类号： A61K31/4725 ; C07D217/24 ; A61K31/472 ; A61P9/12 ; A61P9/10 ; A61P13/12 ; A61P35/00 ; A61P25/00
摘要：
The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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