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1.发明申请公开(公告)号：US20110190340A1
公开(公告)日：2011-08-04
申请号：US13000202
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D217/24 , A61K31/472 , A61P9/12 , A61P9/10 , A61P13/12 , A61P35/00 , A61P25/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
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2.发明授权公开(公告)号：US08524737B2
公开(公告)日：2013-09-03
申请号：US13000202
申请日：2009-06-18
IPC分类号： C07D495/08 , C07D217/24 , A61K31/47
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R1 to R12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的双和多环取代的异喹啉和异喹啉酮，其中R 1至R 12如本申请中所定义，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的相关疾病 肌球蛋白轻链磷酸酶的磷酸化，以及含有这些化合物的组合物。
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3.发明授权公开(公告)号：US08710077B2
公开(公告)日：2014-04-29
申请号：US12487503
申请日：2009-06-18
申请人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
发明人： Oliver Plettenburg , Katrin Lorenz , Jochen Goerlitzer , Matthias Löhn , Sandrine Biscarrat , Fréderic Jeannot , Olivier Duclos
IPC分类号： A61K31/47 , C07D217/00
CPC分类号： C07D217/24
摘要： The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异喹啉酮衍生物， 化合物。
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![5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases](/abs-image/US/2015/03/10/US08975250B2/abs.jpg.150x150.jpg)
4.发明授权5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases 有权5氧代-5,8-二氢吡啶并[2,3-d]嘧啶衍生物作为治疗心血管疾病的CaMKII激酶抑制剂公开(公告)号：US08975250B2
公开(公告)日：2015-03-10
申请号：US13544209
申请日：2012-07-09
IPC分类号： C07D471/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P1/16 , A61P13/12 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P9/00 , A61P9/06 , A61P9/10 , C07D239/47
CPC分类号： C07D471/04
摘要： The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives having Formula (I) as defined herein, their preparation and their therapeutic use.
摘要翻译： 本发明涉及如本文所定义的具有式（I）的5-氧代-5,8-二氢吡啶并[2,3-d]嘧啶衍生物，其制备及其治疗用途。
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5.发明授权Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics 有权7-炔基-1,8-萘啶酮衍生物的制备方法及其在治疗中的应用公开(公告)号：US08470847B2
公开(公告)日：2013-06-25
申请号：US12631122
申请日：2009-12-04
申请人： Antoine Alam , Sandrine Biscarrat , Isabelle Blanc , Françoise Bono , Olivier Duclos , Gary Mccort
发明人： Antoine Alam , Sandrine Biscarrat , Isabelle Blanc , Françoise Bono , Olivier Duclos , Gary Mccort
IPC分类号： C07D471/02 , A01N43/42 , A61K31/44
CPC分类号： C07D213/73 , C07D213/82 , C07D471/04
摘要： The disclosure relates to 7-alkynyl-1,8-naphthyridones of formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and to their use in therapeutics.
摘要翻译： 本公开涉及式（I）的7-炔基-1,8-萘啶酮：其中R1，R2，R3和R4如本公开所定义，含有它们的组合物，其制备方法及其用途 在治疗。
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