发明申请
US20110190503A1 Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
审中-公开
噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂
- 专利标题： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
- 专利标题（中）： 噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂
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申请号： US13039105申请日： 2011-03-02
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公开(公告)号： US20110190503A1公开(公告)日： 2011-08-04
- 发明人: Genesis M. BACANI , Diego BROGGINI , Eugene Y. CHEUNG , Christa C. CHROVIAN , Xiaohu DENG , Anne M. FOURIE , Laurent GOMEZ , Cheryl A. GRICE , Aaron M. KEARNEY , Adrienne M. LANDRY-BAYLE , Alice LEE-DUTRA , Jimmy T. LIANG , Susanne LOCHNER , Neelakandha S. MANI , Alejandro SANTILLÁN, JR. , Kathleen SAPPEY , Kia SEPASSI , Virginia M. TANIS , Alvah T. WICKBOLDT , John J. M. WIENER , Hartmut ZINSER
- 申请人： Genesis M. BACANI , Diego BROGGINI , Eugene Y. CHEUNG , Christa C. CHROVIAN , Xiaohu DENG , Anne M. FOURIE , Laurent GOMEZ , Cheryl A. GRICE , Aaron M. KEARNEY , Adrienne M. LANDRY-BAYLE , Alice LEE-DUTRA , Jimmy T. LIANG , Susanne LOCHNER , Neelakandha S. MANI , Alejandro SANTILLÁN, JR. , Kathleen SAPPEY , Kia SEPASSI , Virginia M. TANIS , Alvah T. WICKBOLDT , John J. M. WIENER , Hartmut ZINSER
- 专利权人： Janssen Pharmaceutical NV
- 当前专利权人： Janssen Pharmaceutical NV
- 主分类号： C07D451/02
- IPC分类号： C07D451/02
摘要：
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
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