公开(公告)号：US08357684B2

公开(公告)日：2013-01-22

申请号：US13039017

申请日：2011-03-02

Applicant: Genesis M. Bacani ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Alejandro Santillán, Jr. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener

Inventor： Genesis M. Bacani ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Alejandro Santillán, Jr. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener

IPC: A61K31/5355 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/497 ,  A61K31/4365 ,  C07D413/14 ,  C07D239/34 ,  C07D513/04

CPC classification number: C07D498/04 ,  C07D451/02

Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

Abstract translation: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。

公开(公告)号：US20110159563A1

公开(公告)日：2011-06-30

申请号：US13039017

申请日：2011-03-02

Applicant: Genesis M. Bacani ,  Diego Broggini ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Xiaohu Deng ,  Anne M. Fourie ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Jimmy T. Liang ,  Susanne Lochner ,  Neelakandha S. Mani ,  Alejandro Santillán, JR. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener ,  Hartmut Zinser

Inventor： Genesis M. Bacani ,  Diego Broggini ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Xiaohu Deng ,  Anne M. Fourie ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Jimmy T. Liang ,  Susanne Lochner ,  Neelakandha S. Mani ,  Alejandro Santillán, JR. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener ,  Hartmut Zinser

IPC: C12N9/99 ,  C07D513/04

CPC classification number: C07D498/04 ,  C07D451/02

Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

Abstract translation: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。

公开(公告)号：US07939527B2

公开(公告)日：2011-05-10

申请号：US12421406

申请日：2009-04-09

Applicant: Genesis M. Bacani ,  Diego Broggini ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Xiaohu Deng ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Jimmy T. Liang ,  Susanne Lochner ,  Neelakandha S. Mani ,  Alejandro Santillán, Jr. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener ,  Hartmut Zinser

Inventor： Genesis M. Bacani ,  Diego Broggini ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Xiaohu Deng ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Jimmy T. Liang ,  Susanne Lochner ,  Neelakandha S. Mani ,  Alejandro Santillán, Jr. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener ,  Hartmut Zinser

IPC: A61K31/5355 ,  A61K31/4985 ,  A61K31/516 ,  A61K31/497 ,  A61K31/4365 ,  C07D413/14 ,  C07D239/34 ,  C07D513/04

CPC classification number: C07D498/04 ,  C07D451/02

Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

公开(公告)号：US20090099157A1

公开(公告)日：2009-04-16

申请号：US12031551

申请日：2008-02-14

Applicant: Michael K. Ameriks ,  Kristen L. Arienti ,  James P. Edwards ,  Cheryl A. Grice ,  Todd K. Jones ,  Alice Lee-Dutra ,  Jing Liu ,  Neelakandha S. Mani ,  Danielle K. Neff ,  Alvah T. Wickboldt ,  John J.M. Wiener

Inventor： Michael K. Ameriks ,  Kristen L. Arienti ,  James P. Edwards ,  Cheryl A. Grice ,  Todd K. Jones ,  Alice Lee-Dutra ,  Jing Liu ,  Neelakandha S. Mani ,  Danielle K. Neff ,  Alvah T. Wickboldt ,  John J.M. Wiener

IPC: A61K31/551 ,  C07D471/04 ,  A61K31/5377 ,  A61P9/10 ,  A61P37/08 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Abstract translation: 描述了四氢吡唑并吡啶硫醚化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。

公开(公告)号：US20110190503A1

公开(公告)日：2011-08-04

申请号：US13039105

申请日：2011-03-02

Applicant: Genesis M. BACANI ,  Diego BROGGINI ,  Eugene Y. CHEUNG ,  Christa C. CHROVIAN ,  Xiaohu DENG ,  Anne M. FOURIE ,  Laurent GOMEZ ,  Cheryl A. GRICE ,  Aaron M. KEARNEY ,  Adrienne M. LANDRY-BAYLE ,  Alice LEE-DUTRA ,  Jimmy T. LIANG ,  Susanne LOCHNER ,  Neelakandha S. MANI ,  Alejandro SANTILLÁN, JR. ,  Kathleen SAPPEY ,  Kia SEPASSI ,  Virginia M. TANIS ,  Alvah T. WICKBOLDT ,  John J. M. WIENER ,  Hartmut ZINSER

Inventor： Genesis M. BACANI ,  Diego BROGGINI ,  Eugene Y. CHEUNG ,  Christa C. CHROVIAN ,  Xiaohu DENG ,  Anne M. FOURIE ,  Laurent GOMEZ ,  Cheryl A. GRICE ,  Aaron M. KEARNEY ,  Adrienne M. LANDRY-BAYLE ,  Alice LEE-DUTRA ,  Jimmy T. LIANG ,  Susanne LOCHNER ,  Neelakandha S. MANI ,  Alejandro SANTILLÁN, JR. ,  Kathleen SAPPEY ,  Kia SEPASSI ,  Virginia M. TANIS ,  Alvah T. WICKBOLDT ,  John J. M. WIENER ,  Hartmut ZINSER

IPC: C07D451/02

CPC classification number: C07D498/04 ,  C07D451/02

Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

Abstract translation: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。

公开(公告)号：US20090258854A1

公开(公告)日：2009-10-15

申请号：US12421406

申请日：2009-04-09

Applicant: Genesis M. Bacani ,  Diego Broggini ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Xiaohu Deng ,  Anne M. Fourie ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearny ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Jimmy T. Liang ,  Susanne Lochner ,  Neelakandha S. Mani ,  Alejandro Santillan, JR. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener ,  Hartmut Zinser

Inventor： Genesis M. Bacani ,  Diego Broggini ,  Eugene Y. Cheung ,  Christa C. Chrovian ,  Xiaohu Deng ,  Anne M. Fourie ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearny ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Jimmy T. Liang ,  Susanne Lochner ,  Neelakandha S. Mani ,  Alejandro Santillan, JR. ,  Kathleen Sappey ,  Kia Sepassi ,  Virginia M. Tanis ,  Alvah T. Wickboldt ,  John J. M. Wiener ,  Hartmut Zinser

IPC: A61K31/437 ,  C07D513/04 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/4985 ,  A61P29/00 ,  C12N9/50 ,  C07D453/02

CPC classification number: C07D498/04 ,  C07D451/02

Abstract: Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

Abstract translation: 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。

公开(公告)号：US20080200454A1

公开(公告)日：2008-08-21

申请号：US12031010

申请日：2008-02-14

Applicant: Michael K. Ameriks ,  Frank U. Axe ,  James P. Edwards ,  Cheryl A. Grice ,  Hui Cai ,  Elizabeth Ann Gleason ,  Steven P. Meduna ,  Kevin L. Tays ,  John J. M. Wiener ,  Alvah T. Wickboldt

Inventor： Michael K. Ameriks ,  Frank U. Axe ,  James P. Edwards ,  Cheryl A. Grice ,  Hui Cai ,  Elizabeth Ann Gleason ,  Steven P. Meduna ,  Kevin L. Tays ,  John J. M. Wiener ,  Alvah T. Wickboldt

IPC: A61K31/437 ,  A61P37/00 ,  A61P29/00 ,  A61P1/00 ,  A61P25/00 ,  A61P35/00 ,  A61K31/496 ,  A61K31/541 ,  A61K31/55 ,  A61P17/00 ,  A61P3/10 ,  A61P11/00 ,  C07D471/04 ,  A61K31/53

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.

Abstract translation: 描述了碳连接的四氢 - 吡唑并 - 吡啶化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。