发明申请
- 专利标题： PROCESSES OF SYNTHESIZING DIHYDROPYRIDOPHTHALAZINONE DERIVATIVES
- 专利标题（中）： 合成二羟基二苯基酮衍生物的方法
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申请号： US13023140申请日： 2011-02-08
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公开(公告)号： US20110196153A1公开(公告)日： 2011-08-11
- 发明人: Bing Wang , Daniel Chu , Yongbo Liu , Quan Jiang , Lei Lu
- 申请人： Bing Wang , Daniel Chu , Yongbo Liu , Quan Jiang , Lei Lu
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D405/06 ; C07D249/08 ; C07D403/06 ; C07D401/04
摘要：
Provided herein are processes for synthesizing dihydropyridophthalazinone derivatives, such as for example, 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one and its stereoisomers, which are potent poly(ADP-ribose)polymerase (PARP) inhibitors as well as novel synthetic intermediate compounds.
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