Communication devices, systems, and methods for dynamic cell bonding (DCB) for Radio-over-Fiber (RoF)-based networks and communication systems are disclosed. In one embodiment, a method of operating an optical fiber-based wireless communication system is provided. The method includes determining a first plurality of remote units in a cloud bonded to a Radio-over-Fiber (RoF) communication session. The method also includes measuring a received signal strength from each of the first plurality of remote units. The method also includes measuring a received signal strength from each of a second plurality of remote units in the cloud not bonded to the RoF communication session. At least one of the second plurality of remote units is dynamically bonded to the RoF communication session if the measured received signal strength of the one of the second plurality of remote units is greater than the measured received signal strength of the first plurality of remote units.