发明申请
- 专利标题： ANTI-CD147 ANTIBODIES, METHODS AND USES
- 专利标题（中）： 抗CD147抗体，方法和用途
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申请号： US13062702申请日： 2009-08-19
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公开(公告)号： US20110200627A1公开(公告)日： 2011-08-18
- 发明人: Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
- 申请人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
- 国际申请： PCT/US09/54289 WO 20090819
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/42 ; C07K16/00 ; C12N5/09 ; A61P35/00 ; A61P37/04
摘要：
The present invention provides antibodies immunospecific for human CD 147 capable of blocking bioactivity of CD 147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD 147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
公开/授权文献
- US08618264B2 Anti-CD147 antibodies, methods and uses 公开/授权日：2013-12-31
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