发明申请
- 专利标题： LISTERIA ATTENUATED FOR ENTRY INTO NON-PHAGOCYTIC CELLS, VACCINES COMPRISING THE LISTERIA, AND METHODS OF USE THEREOF
- 专利标题（中）： 被引入非糖代谢细胞的肠梗阻，包含肠炎的疫苗及其使用方法
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申请号： US12748586申请日： 2010-03-29
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公开(公告)号： US20110201092A1公开(公告)日： 2011-08-18
- 发明人: Thomas W. Dubensky, JR. , Dirk G. Brockstedt , David N. Cook
- 申请人： Thomas W. Dubensky, JR. , Dirk G. Brockstedt , David N. Cook
- 主分类号： C12N1/20
- IPC分类号： C12N1/20
摘要：
The present invention provides Listeria that are attenuated for entry into non-phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuated Listeria are further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.
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