发明申请
US20110201565A1 LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM
审中-公开
LUTEOLIN AND DIOSMIN / DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TRATING AUTISM
- 专利标题： LUTEOLIN AND DIOSMIN/DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TREATING AUTISM
- 专利标题（中）： LUTEOLIN AND DIOSMIN / DIOSMETIN AS NOVEL STAT3 INHIBITORS FOR TRATING AUTISM
-
申请号： US13093401申请日： 2011-04-25
-
公开(公告)号： US20110201565A1公开(公告)日： 2011-08-18
- 发明人: Jun Tan , Deyan Luo
- 申请人： Jun Tan , Deyan Luo
- 申请人地址： US FL Tampa
- 专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人： UNIVERSITY OF SOUTH FLORIDA
- 当前专利权人地址： US FL Tampa
- 主分类号： A61K31/7048
- IPC分类号： A61K31/7048 ; A61K31/353 ; A61P3/10 ; A61P25/18 ; A61P25/28
摘要：
The present invention includes methods for the treatment of autoimmune disorders such as autism, schizophrenia, and type 1 diabetes. Flavonoids, luteolin, diosmin, and diosmin's aglycone form, diosmetin, were found to inhibit activation/phosphorylation of STAT3 induced by IL-6 in cultured neuronal cells. Furthermore, mice treated with diosmin showed a significant reduction of autistic phenotype induced by IL-6 through inhibition of STAT3 activation.
信息查询
