公开(公告)号：US20200341437A1

公开(公告)日：2020-10-29

申请号：US16396502

申请日：2019-04-26

申请人： Renchang Dai ,  Guangyi Liu ,  Jun Tan ,  Chen Yuan ,  Yi Lu ,  Zhenjiang Yu ,  Zhiwei Wang

发明人： Renchang Dai ,  Guangyi Liu ,  Jun Tan ,  Chen Yuan ,  Yi Lu ,  Zhenjiang Yu ,  Zhiwei Wang

IPC分类号： G05B13/04 ,  G06F16/901 ,  H02J3/06 ,  H04W52/52

摘要： A power system energy management system with security constrained automatic generation control (SCAGC) is disclosed wherein the power generation output and branch power flow are constrained by security limit. A sub-optimization model is used to calculate SCAGC for each control area in parallel. Graph computing is applied to solve the SCAGC by simplex approach in hierarchical parallel and nodal parallel. The SCAGC is solved heuristically first by combining the equal incremental fuel cost ratio and generation shift factor, and if the heuristics do not converge, a simplex method is used to solve the SCAGC.

公开(公告)号：US10149982B2

公开(公告)日：2018-12-11

申请号：US14976986

申请日：2015-12-21

申请人： Gary W. Arendash ,  Chuanhai Cao ,  Jun Tan

发明人： Gary W. Arendash ,  Chuanhai Cao ,  Jun Tan

IPC分类号： A61N2/00 ,  A61N5/02 ,  A61N2/02

摘要： A method of treating and preventing a neurological disorder, such as Alzheimer's disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a predetermined frequency (preferably ≈300-3,000 MHz) for a predetermined absorption period (preferably greater than ≈3 days). Each individual treatment (comprising exposure to the predetermined frequency for the predetermined absorption period) is continued at a predetermined schedule for a predetermined treatment period. The EMF can have a specific absorption rate up to about 8 W/kg. The methodology enhances cognition in the subject and/or treats/prevents the underlying neurological disorder or a symptom thereof.

公开(公告)号：US20180325950A1

公开(公告)日：2018-11-15

申请号：US16035936

申请日：2018-07-16

申请人： Jun Tan ,  Paul R. Sanberg

发明人： Jun Tan ,  Paul R. Sanberg

IPC分类号： A61K35/16 ,  A61K35/44 ,  A61K35/12

CPC分类号： A61K35/16 ,  A61K35/44 ,  A61K2035/122

摘要： Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid angiopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, Aβ phagocytic activity was increased and soluble and insoluble Aβ protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of Aβ1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.

公开(公告)号：US10039785B2

公开(公告)日：2018-08-07

申请号：US15195243

申请日：2016-06-28

申请人： Jun Tan ,  Paul R. Sanberg

发明人： Jun Tan ,  Paul R. Sanberg

IPC分类号： A61K35/12 ,  A61K35/16 ,  A61K35/44

摘要： Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, Aβ phagocytic activity was increased and soluble and insoluble Aβ protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of Aβ1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.

公开(公告)号：US20150157597A1

公开(公告)日：2015-06-11

申请号：US14570625

申请日：2014-12-15

申请人： Jun Tan ,  Frank Fernandez ,  Nan Sun ,  Roland D. Shytle ,  Jared Ehrhart

发明人： Jun Tan ,  Frank Fernandez ,  Nan Sun ,  Roland D. Shytle ,  Jared Ehrhart

IPC分类号： A61K31/353 ,  A61K31/4745

CPC分类号： A61K31/353 ,  A01K2267/0318 ,  A61K31/4745 ,  A61K36/82 ,  C12N2740/16111 ,  C12N2740/16311

摘要： The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or without IFN-γ added, resulting in neuronal death, and simulated neurodegenerative diseases. The neurodegenerative disease is treated using a JAK/STAT pathway inhibitor, including (-)-epigallocatechin-3-gallate (EGCG), to modulate JAK1 or STAT1 phosphorylation, resulting in resistance to gp120 or Tat neurotoxicity. The invention may be used to treat neurons afflicted with HIV-associated Dementia, multiple sclerosis, Alzheimer's Disease, Parkinson's Disease, amyotrophic lateral sclerosis, or Pick's Disease, and may act in conjunction with antiviral treatment, like HAART.

摘要翻译： 本发明涉及用JAK / STAT途径抑制剂治疗神经变性疾病，以消除导致细胞周期消除和/或凋亡的细胞外细胞信号传导事件。 主要神经元被施用神经毒性蛋白质，例如gp120，Tat或gp120和Tat，加入或不加入IFN-γ，导致神经元死亡和模拟的神经变性疾病。 神经变性疾病使用JAK / STAT途径抑制剂（包括（ - ） - 表没食子儿茶素-3-没食子酸酯（EGCG））来调节JAK1或STAT1磷酸化，导致抗gp120或Tat神经毒性。 本发明可用于治疗患有HIV相关性痴呆，多发性硬化，阿尔茨海默氏病，帕金森病，肌萎缩性侧索硬化或皮克病的神经元，并且可以与抗病毒治疗一起起作用，如HAART。

公开(公告)号：US08802638B1

公开(公告)日：2014-08-12

申请号：US12421342

申请日：2009-04-09

申请人： Jun Tan ,  Doug Shytle ,  Kavon Rezai-Zadeh

发明人： Jun Tan ,  Doug Shytle ,  Kavon Rezai-Zadeh

IPC分类号： C07G3/00 ,  A01N43/04 ,  A61K31/70

CPC分类号： C07D311/30 ,  A61K31/7048

摘要： The flavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes presenilin 1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation. GSK-3α activity is essential for both PS1 CTF phosphorylation states and PS1-APP interaction. These findings were validated in vivo, using a Tg2576 Alzheimer's Disease model system. Luteolin treatment decreased soluble Aβ levels, reduced GSK-3 activity, and disrupted PS1-APP association. In addition, Tg2576 mice treated with diosmin, a glycoside of a flavone structurally and functionally similar to luteolin (diosmetin), displayed significantly reduced Aβ pathology as well.

摘要翻译： 类黄酮木犀草素减少淀粉样蛋白 肽（A＆bgr））产生。 木犀草素也是选择性GSK-3抑制剂，1）降低淀粉样蛋白原γ分泌酶APP处理，2）促进早老素1（PS1）羧基末端片段（CTF）磷酸化。 GSK-3α活性对于PS1 CTF磷酸化状态和PS1-APP相互作用都是至关重要的。 使用Tg2576阿尔茨海默病模型系统在体内证实了这些发现。 木犀草素处理降低了可溶性A＆bgr; 水平，降低GSK-3活性，并破坏PS1-APP关联。 此外，用diosmin（在结构上和功能上类似于木犀草素（diosmetin）的黄酮的糖苷）处理的Tg2576小鼠显示出显着降低的A＆bgr; 病理学以及。

公开(公告)号：US08527925B2

公开(公告)日：2013-09-03

申请号：US13463857

申请日：2012-05-04

申请人： Hong Wei Dai ,  Gong Qiong Li ,  Jia Niu ,  Jun Tan

发明人： Hong Wei Dai ,  Gong Qiong Li ,  Jia Niu ,  Jun Tan

IPC分类号： G06F17/50

CPC分类号： G06F17/5068 ,  G06F2217/62 ,  G06F2217/84

摘要： The present invention relates to a method and an apparatus for estimating a clock skew. The method comprises: obtaining a basic clock skew of each clock tree in the circuit; judging whether two units are in a same clock domain; if they are in different clock domains, estimating the clock skew between units to be a larger one of basic clock skews of the clock trees corresponding to these two unit; if these two units are in the same clock domain, further judging whether they are in a same hierarchical logic block; if they are in different hierarchical logic blocks, estimating the clock skew between units to be the basic clock skew of the clock tree of these two units plus additional clock skew caused by different hierarchical logic blocks. The apparatus is corresponding to the method. With the method and apparatus, the clock skew in the circuit can be estimated more accurately, which improves the efficiency of circuit design.

摘要翻译： 本发明涉及一种用于估计时钟偏差的方法和装置。 该方法包括：获得电路中每个时钟树的基本时钟偏差; 判断两个单元是否处于相同的时钟域; 如果它们在不同的时钟域中，则将单元之间的时钟偏差估计为对应于这两个单元的时钟树的基本时钟偏差中较大的一个; 如果这两个单元在相同的时钟域中，则进一步判断它们是否处于相同的分层逻辑块中; 如果它们处于不同的分层逻辑块中，则估计单元之间的时钟偏差将成为这两个单元的时钟树的基本时钟偏差，以及由不同分层逻辑块引起的附加时钟偏移。 该装置对应于该方法。 利用该方法和装置，可以更精确地估计电路中的时钟偏移，这提高了电路设计的效率。

公开(公告)号：US08471703B2

公开(公告)日：2013-06-25

申请号：US13048950

申请日：2011-03-16

申请人： Jie-Jun Tan ,  Hua Dong ,  Yu-Long Lin ,  Yi-Yong Xie

发明人： Jie-Jun Tan ,  Hua Dong ,  Yu-Long Lin ,  Yi-Yong Xie

IPC分类号： G08B21/00

CPC分类号： G06F11/3055 ,  G06F11/3031

摘要： A network status indication system utilizes indicators on a keyboard to indicate the network status of a computer. When a simultaneous activation of two predetermined keys is detected and when the number of simultaneous activations is odd, the network status is determined, thereby indicating the network status of the computer.

摘要翻译： 网络状态指示系统利用键盘上的指示器来指示计算机的网络状态。 当检测到两个预定密钥的同时激活时，当同时激活的数量为奇数时，确定网络状态，从而指示计算机的网络状态。

公开(公告)号：US20120331280A1

公开(公告)日：2012-12-27

申请号：US13449296

申请日：2012-04-17

申请人： YU-LONG LIN ,  HUA DONG ,  JIE-JUN TAN ,  JUN ZHANG

发明人： YU-LONG LIN ,  HUA DONG ,  JIE-JUN TAN ,  JUN ZHANG

IPC分类号： G06F9/06

CPC分类号： G06F9/4401

摘要： In a method of burning a firmware to an embedded device, a booting file is firstly created and saved in the firmware. The booting file includes a boot loader, a first kernel, a second kernel, a first initrd, a second initrd of a firmware, a rootfs, and an application program. The method burns the boot loader, the first kernel, the second kernel, the first initrd, and the second initrd in a flash memory of the embedded device. When the rootfs and the application program are recorded in a storage system of the embedded device, the method downloads the rootfs and the application program from a storage system of the embedded device, and burns the rootfs and the application program to a register of the flash memory.

摘要翻译： 在将固件刻录到嵌入式设备的方法中，首先创建引导文件并将其保存在固件中。 引导文件包括引导加载程序，第一内核，第二内核，第一initrd，固件的第二initrd，rootfs和应用程序。 该方法在嵌入式设备的闪存中刻录引导加载程序，第一个内核，第二个内核，第一个initrd和第二个initrd。 当rootfs和应用程序被记录在嵌入式设备的存储系统中时，该方法从嵌入式设备的存储系统下载rootfs和应用程序，并将rootfs和应用程序烧录到闪存的​​寄存器 记忆。

公开(公告)号：US20120016617A1

公开(公告)日：2012-01-19

申请号：US12944750

申请日：2010-11-12

申请人： YU-LONG LIN ,  HUA DONG ,  JIE-JUN TAN ,  YI-YONG XIE

发明人： YU-LONG LIN ,  HUA DONG ,  JIE-JUN TAN ,  YI-YONG XIE

IPC分类号： G06F19/00

CPC分类号： G06F11/26

摘要： A method for testing an electronic device is implemented with a host computer. The host computer detects a test status of the electronic device. The host computer stores a test order table that indicates the test status and test order corresponding to the test status. The host computer transmits a test order based on the test status and the test order table to the electronic device. The electronic device executes a self-test based on the test order.

摘要翻译： 用主计算机实现电子设备的测试方法。 主机检测电子设备的测试状态。 主计算机存储指示与测试状态对应的测试状态和测试顺序的测试顺序表。 主计算机根据测试状态和测试顺序表将测试顺序发送到电子设备。 电子设备根据测试顺序执行自检。