发明申请
US20110206687A1 Isolation And Purification Of Anti-IL-13 Antibodies Using Protein A Affinity Chromatography
有权
使用蛋白A亲和色谱法分离和纯化抗IL-13抗体
- 专利标题： Isolation And Purification Of Anti-IL-13 Antibodies Using Protein A Affinity Chromatography
- 专利标题（中）： 使用蛋白A亲和色谱法分离和纯化抗IL-13抗体
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申请号： US12908502申请日： 2010-10-20
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公开(公告)号： US20110206687A1公开(公告)日： 2011-08-25
- 发明人: Robert K. Hickman
- 申请人： Robert K. Hickman
- 申请人地址： US IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： US IL Abbott Park
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; A61P29/00 ; A61P19/02
摘要：
Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.