发明申请
US20110212845A1 Biomarkers for predicting the sensitivity and response of protein kinase CK2-mediated diseases to CK2 Inhibitors
审中-公开
用于预测蛋白激酶CK2介导的疾病对CK2抑制剂的敏感性和反应的生物标志物
- 专利标题： Biomarkers for predicting the sensitivity and response of protein kinase CK2-mediated diseases to CK2 Inhibitors
- 专利标题（中）： 用于预测蛋白激酶CK2介导的疾病对CK2抑制剂的敏感性和反应的生物标志物
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申请号： US12897640申请日： 2010-10-04
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公开(公告)号： US20110212845A1公开(公告)日： 2011-09-01
- 发明人: Denis DRYGIN , Sean E. O'BRIEN , Kenna L. ANDERES , Daniel VON HOFF , John K.C. LIM , Claire S. PADGETT , Joshua R. BLIESATH , Caroline B. HO , William G. Rice
- 申请人： Denis DRYGIN , Sean E. O'BRIEN , Kenna L. ANDERES , Daniel VON HOFF , John K.C. LIM , Claire S. PADGETT , Joshua R. BLIESATH , Caroline B. HO , William G. Rice
- 主分类号： C40B30/00
- IPC分类号： C40B30/00 ; C12Q1/48 ; C12Q1/02 ; C12Q1/68 ; G01N33/53
摘要：
Disclosed are biomarkers for determining the sensitivity of protein kinase CK2-mediated diseases, such as proliferative and/or inflammatory disorders, to treatment with CK2 inhibitors. These biomarkers can be used to predict or select subjects likely to be responsive to treatment with a CK2 inhibitor, and to treat or monitor subjects undergoing treatment with a CK2 inhibitor.