Infusion sets for insertion into an insertion site for preventing misalignment of the base and cap or fluid connector by providing one or more alignment features between each, and in alternative embodiments, provide one or more features to secure the cap or fluid connector to the base in anyone of a number of rotational positions and having release features to allow the cap or fluid connector to be rotatable with respect to the base portion of the infusion set, and yet easily removed and inserted. Further embodiments provide infusion sets wherein the user can easily see the insertion site of the catheter and the skin, to determine if infections have occurred at an earlier stage than was possible using prior art infusion sets and with substantially less difficulty.