This invention discloses a bit-stuffing method for crosstalk avoidance in high-speed buses, which comprises the steps of inputting a plurality of data bit streams in parallel to a data input buffer; the data input buffer sequentially inputting data bits of the data bit streams to a bit-switching unit, and the bit-switching unit switching the data bits to generate bit-switched data; parallelly inputting the bit-switched data to a bit-stuffing encoding unit; the bit-stuffing encoding unit performing bit-stuffing encoding on the bit-switched data to generate encoded data bits and inputting the encoded data bits to an encoded data buffer; and the encoded data buffer outputting the encoded data to a high-speed bus. The encoded data bits passed through the high-speed bus are decoded using a bit-removing method to recover the data bit streams.