发明申请
US20110230542A1 Compositions and Methods for Inhibiting Expression of the PCSK9 Gene
有权
抑制PCSK9基因表达的组合物和方法
- 专利标题： Compositions and Methods for Inhibiting Expression of the PCSK9 Gene
- 专利标题（中）： 抑制PCSK9基因表达的组合物和方法
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申请号： US12554231申请日： 2009-09-04
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公开(公告)号： US20110230542A1公开(公告)日： 2011-09-22
- 发明人: Pamela Tan , Birgit Bramlage , Maria Frank-Kamenetsky , Kevin Fitzgerald , Akin Akinc , Victor E. Kotelianski
- 申请人： Pamela Tan , Birgit Bramlage , Maria Frank-Kamenetsky , Kevin Fitzgerald , Akin Akinc , Victor E. Kotelianski
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; C12N5/00 ; C07H21/02 ; A61P3/06
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; and
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