发明申请
- 专利标题: Low-Substituted Hydroxypropylcellulose and Solid Preparation Comprising the Same
- 专利标题(中): 低取代羟丙基纤维素和包含其的固体制剂
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申请号: US13043113申请日: 2011-03-08
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公开(公告)号: US20110230656A1公开(公告)日: 2011-09-22
- 发明人: Naosuke Maruyama , Yasuyuki Hirama
- 申请人: Naosuke Maruyama , Yasuyuki Hirama
- 专利权人: Shin-Etsu Chemical Co., Ltd.
- 当前专利权人: Shin-Etsu Chemical Co., Ltd.
- 优先权: JP2010-062484 20100318
- 主分类号: C08B11/08
- IPC分类号: C08B11/08
摘要:
Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1): Crystallinity(%)={(Ic−Ia)/Ic}×100 (1) wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.