发明申请
US20110230656A1 Low-Substituted Hydroxypropylcellulose and Solid Preparation Comprising the Same 有权
低取代羟丙基纤维素和包含其的固体制剂

Low-Substituted Hydroxypropylcellulose and Solid Preparation Comprising the Same
摘要:
Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1): Crystallinity(%)={(Ic−Ia)/Ic}×100  (1) wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.
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