公开(公告)号：US08822675B2

公开(公告)日：2014-09-02

申请号：US13043113

申请日：2011-03-08

申请人： Naosuke Maruyama ,  Yasuyuki Hirama

发明人： Naosuke Maruyama ,  Yasuyuki Hirama

IPC分类号： C08B11/08 ,  A61K31/167 ,  A61K9/00 ,  A61K47/18 ,  C08B11/02 ,  A61K9/20

CPC分类号： C08B11/02 ,  A61K9/0056 ,  A61K9/2054 ,  A61K31/167 ,  A61K47/18

摘要： Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1): Crystallinity(%)={(Ic−Ia)/Ic}×100  (1) wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.

摘要翻译： 本发明提供了具有改进的可压缩性和流动性的非离子和非常稳定的低取代羟丙基纤维素，并且还具有口腔改善的崩解和质地。 更具体地提供了结晶度为60％以下，羟丙氧基取代度为5〜9重量％，长径比小于2.5的低取代羟丙基纤维素，其中结晶度基于衍射强度由 根据下式（1）的广角X射线衍射测定：结晶度（％）= {（Ic-Ia）/ Ic}×100（1）其中，Ic表示衍射角2°时的衍射强度; 为22.5°，Ia表示衍射角2°时的衍射强度; 为18.5°。

公开(公告)号：US20110230656A1

公开(公告)日：2011-09-22

申请号：US13043113

申请日：2011-03-08

申请人： Naosuke Maruyama ,  Yasuyuki Hirama

发明人： Naosuke Maruyama ,  Yasuyuki Hirama

IPC分类号： C08B11/08

CPC分类号： C08B11/02 ,  A61K9/0056 ,  A61K9/2054 ,  A61K31/167 ,  A61K47/18

摘要： Provided is nonionic and excellently stable low-substituted hydroxypropylcellulose having improved compressibility and flowability, and further having improved disintegration and texture in oral cavity. More specifically provided is low-substituted hydroxypropylcellulose having a crystallinity of 60% or less, a degree of hydroxypropoxyl substitution of 5 to 9% by weight, and an aspect ratio of less than 2.5, wherein the crystallinity is calculated based on a diffraction intensity by wide-angle X-ray diffraction measurement according to the following formula (1): Crystallinity(%)={(Ic−Ia)/Ic}×100  (1) wherein Ic means a diffraction intensity at a diffraction angle 2θ of 22.5° and Ia means a diffraction intensity at a diffraction angle 2θ of 18.5°.

摘要翻译： 本发明提供了具有改进的可压缩性和流动性的非离子和非常稳定的低取代羟丙基纤维素，并且还具有口腔改善的崩解和质地。 更具体地提供了结晶度为60％以下，羟丙氧基取代度为5〜9重量％，长径比小于2.5的低取代羟丙基纤维素，其中结晶度基于衍射强度由 根据下式（1）的广角X射线衍射测定：结晶度（％）= {（Ic-Ia）/ Ic}×100（1）其中，Ic表示衍射角2°时的衍射强度; 为22.5°，Ia表示衍射角2°时的衍射强度; 为18.5°。