发明申请
- 专利标题： Ultrasound Contrast Agents And Process For The Preparation Thereof
- 专利标题（中）： 超声对比剂及其制备方法
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申请号： US13039838申请日： 2011-03-03
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公开(公告)号： US20110236320A1公开(公告)日： 2011-09-29
- 发明人: Michel Schneider , Philippe Bussat , Feng Yan , Christian Guillot
- 申请人： Michel Schneider , Philippe Bussat , Feng Yan , Christian Guillot
- 申请人地址： CH Manno
- 专利权人： BRACCO SUISSE S.A.
- 当前专利权人： BRACCO SUISSE S.A.
- 当前专利权人地址： CH Manno
- 优先权： EP03002375.8 20030204
- 主分类号： A61B8/00
- IPC分类号： A61B8/00 ; A61K9/00 ; A61P43/00
摘要：
Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbubbles with a diameter of 1.5 μm or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles.
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