-
1.发明授权公开(公告)号：US11607196B2
公开(公告)日：2023-03-21
申请号：US16167346
申请日：2018-10-22
申请人： Bracco Suisse S.A.
发明人： Peter Frinking , Nicolas Rognin , Marcel Arditi
摘要： An embodiment includes analyzing a body part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with at least a first passage during an analysis interval. The analyzing includes providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent.
-
公开(公告)号：US10682429B2
公开(公告)日：2020-06-16
申请号：US15536393
申请日：2015-12-17
申请人： BRACCO SUISSE S.A.
发明人： Philippe Bussat , Anne Lassus
摘要： Suspension of gas-filled microvesicles comprising a targeting ligand for binding to KDR or VEGF/KDR complex. The suspension is obtained by reconstituting a freeze-dried residue with a carbohydrate-containing solution in the presence of a physiologically acceptable gas and is stabilized by the presence of histidine.
-
3.发明申请公开(公告)号：US20190053791A1
公开(公告)日：2019-02-21
申请号：US16167346
申请日：2018-10-22
申请人： Bracco Suisse S.A.
发明人： Peter Frinking , Nicolas Rognin , Marcel Arditi
摘要： An embodiment is proposed for analyzing a body-part perfused with a contrast agent, which has been pre-administered as a bolus to circulate through the body-part with a first passage and possibly with at least one second passage during an analysis interval. A corresponding data-processing method includes the steps of providing at least one input signal indicative of a response to an interrogation signal of a corresponding location of the body-part during the analysis interval, and fitting each input signal over the analysis interval by an instance of a combined bolus function of time, based on a combination of a first simple bolus function of time modeling the first passage of the contrast agent and at least one second simple bolus function of time each one modeling a corresponding second passage of the contrast agent, being defined by the values of a set of first fitting parameters of the first simple bolus function, a set of second fitting parameters of each second simple bolus function and a delay parameter of each second simple bolus function with respect to the first simple bolus function. In an embodiment, the step of fitting each input signal includes estimating a peak instant of the input signal when the corresponding response reaches an absolute peak, setting a truncation interval within the analysis interval according to the peak instant, fitting a truncated signal defined by the input signal over the truncation interval by an instance of a truncated simple bolus function of time, modeling a single passage of the contrast agent during the truncation interval, being defined by the values of a set of truncated fitting parameters, and initializing the first fitting parameters, the second fitting parameters of each second simple bolus function and the delay parameter of each second simple bolus function according to the values of the truncated fitting parameters.
-
公开(公告)号：US09446156B2
公开(公告)日：2016-09-20
申请号：US12440009
申请日：2007-09-04
申请人： Stephane Gorgerat , Christian Guillot , Feng Yan
发明人： Stephane Gorgerat , Christian Guillot , Feng Yan
CPC分类号： A61K49/223 , A61K49/1818 , A61K51/1251
摘要： Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.
摘要翻译： 用于诊断和/或治疗方法的图像增强造影剂，特别是以气体填充的微泡的形式，具有增强的稳定性。 气体填充的微泡由一层两亲性材料稳定，并含有0.15％至1.0％（摩尔）含有亲水性聚合物的脂质。 含有亲水性聚合物的脂质优选为与聚乙二醇连接的磷脂。
-
公开(公告)号：US09381258B2
公开(公告)日：2016-07-05
申请号：US13948505
申请日：2013-07-23
申请人： BRACCO SUISSE SA
发明人： Philippe Bussat , Samir Cherkaoui , Hong (Helen) Fan , Bernard Lamy , Palaniappa Nanjappan , Radhakrishna K. Pillai , Sibylle Pochon , Bo Song , Rolf E. Swenson
CPC分类号： A61K49/223 , A61K38/00 , A61K47/544 , A61K47/60 , A61K47/62 , A61K49/227 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58
摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
-
公开(公告)号：US09333273B2
公开(公告)日：2016-05-10
申请号：US14927865
申请日：2015-10-30
申请人： BRACCO SUISSE S.A.
CPC分类号： A61K49/223 , A61K38/178 , A61K49/221 , A61K49/222 , A61K49/227
摘要： Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.
摘要翻译： 与包含氨基酸序列的多肽相关的充气微泡，所述序列对选择素特别是对选择素具有结合亲合力。 充气微泡可用于超声成像。
-
7.发明授权Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis 有权基于流动动力学分析的医学成像应用中固定化造影剂的检测公开(公告)号：US09198639B2
公开(公告)日：2015-12-01
申请号：US12084933
申请日：2006-11-09
申请人： Peter Frinking , Marcel Arditi , Nicolas Rognin , Feng Yan
发明人： Peter Frinking , Marcel Arditi , Nicolas Rognin , Feng Yan
CPC分类号： A61B8/481 , A61B8/08 , G01S7/52026 , G01S7/52038 , G01S7/52041 , G01S7/52071 , G01S7/52074
摘要： A system for facilitating the detection of an immobilized contrast agent in medical imaging applications is proposed. The system includes means for providing a sequence of a total number of input images obtained at corresponding acquisition instants by imaging a body-part of a patient subjected to an administration of a contrast agent capable of circulating within the patient and of being substantially immobilized on a biological target, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding portion of the body-part possibly including said contrast agent, and means for reducing a contribution of the circulating contrast agent within the body-part in at least one selected input image; the means for reducing includes means for creating a filtered image corresponding to each selected input image by replacing a set of input values of the selected input image with a set of corresponding filtered values, each filtered value being representative of the lowest response of the corresponding portion of the body-part in a set of multiple input images including the selected input image, the set of multiple input images consisting of a number of input images lower than the total number.
摘要翻译： 提出了一种便于在医学成像应用中检测固定的造影剂的系统。 该系统包括用于提供在对应的获取时刻获得的输入图像的总数的序列的装置，其通过对经受施用能够在患者内循环的造影剂并且基本上固定在患者身上的患者的体部成像 每个输入图像包括多个输入值，每个输入值指示对可能包括所述造影剂的身体部分的对应部分的询问信号的响应;以及用于减少循环造影剂在所述生物靶内的贡献的装置 至少一个所选输入图像中的身体部分; 用于减少的装置包括用于通过用一组相应的滤波值替换所选择的输入图像的一组输入值来创建与每个所选择的输入图像相对应的滤波图像的装置，每个滤波值代表相应部分的最低响应 包括所选择的输入图像的一组多个输入图像中的身体部分的多个输入图像组合，所述多个输入图像由少于总数的多个输入图像组成。
-
8.发明授权Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds 有权靶向和治疗化合物和包含所述化合物的充气微泡公开(公告)号：US08293214B2
公开(公告)日：2012-10-23
申请号：US12448401
申请日：2007-12-19
CPC分类号： A61K49/223
摘要： New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein: M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.
摘要翻译： 可以掺入气体填充微泡组合物中的新靶向或治疗化合物。 本发明还涉及用于诊断和/或治疗用途的充气微泡，其包含所述化合物及其使用方法。 新化合物是式M-S-T的化合物，其中：M表示能与气体填充的微泡的包膜缔合的成分; T表示包含靶向配体或治疗剂的组分; S表示包含至少两个双砜基团的组分。
-
公开(公告)号：US20110245664A1
公开(公告)日：2011-10-06
申请号：US13133572
申请日：2009-12-15
申请人： Laurent Jakob , Frederic Rivas
发明人： Laurent Jakob , Frederic Rivas
CPC分类号： A61M5/1782 , A61M5/162 , A61M5/204 , A61M5/31553 , A61M2005/3114
摘要： A device for administering a liquid preparation comprising a pharmaceutical agent, particularly a contrast agent, in the form of a bolus. The device comprises in particular a core cylinder and an external cylinder, the core cylinder comprising a conduit (107) and a cylindrical reservoir (108) cooperating with a respective plunger (109), wherein the plunger is modified in order to operatively engage with guiding means (300) provided on the external cylinder.
摘要翻译： 一种用于施用包含药丸剂，特别是造影剂的药剂的液体制剂的装置。 该装置特别包括一个芯筒和一个外筒，该芯筒包括与相应的柱塞（109）配合的导管（107）和圆柱形容器（108），其中柱塞被改型以与引导 设在外筒上的装置（300）。
-
公开(公告)号：US20170348401A1
公开(公告)日：2017-12-07
申请号：US15536458
申请日：2015-12-21
申请人： BRACCO SUISSE SA
发明人： Gilles BIOLEY , Philippe BUSSAT , Blaise CORTHESY , Anne LASSUS
IPC分类号： A61K39/00
摘要： Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
-
-
-
-
-
-
-
-
-
搜索结果
48 条记录 (耗时 0.039 秒)
