发明申请
US20110237583A1 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
有权
2，5-二氨基取代的吡啶[4,3-D]吡啶类作为对癌症的自身免疫抑制剂
![2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER](/docs/US/2011-09-29/US20110237583A1/abs.jpg.600x600.jpg)
- 专利标题： 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
- 专利标题（中）： 2，5-二氨基取代的吡啶[4,3-D]吡啶类作为对癌症的自身免疫抑制剂
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申请号： US13132181申请日： 2009-11-03
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公开(公告)号： US20110237583A1公开(公告)日： 2011-09-29
- 发明人: Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
- 申请人： Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
- 专利权人： MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- 当前专利权人： MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
- 优先权： EP08020824.2 20081201
- 国际申请： PCT/EP09/07876 WO 20091103
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D471/04 ; A61K31/519 ; C12N9/99 ; A61P35/00 ; A61P35/02 ; A61P9/10 ; A61P9/00 ; A61P27/02 ; A61P29/00 ; A61P19/02 ; A61P25/28 ; A61P37/06 ; A61P17/02
![2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER](/abs-image/US/2011/09/29/US20110237583A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
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