- 专利标题： Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
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申请号： US12971226申请日： 2010-12-17
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公开(公告)号： US20110237601A1公开(公告)日： 2011-09-29
- 发明人: Kenneth G. Carson , Prakash Raman , Francois Soucy , Qing Ye , Shomir Ghosh
- 申请人： Kenneth G. Carson , Prakash Raman , Francois Soucy , Qing Ye , Shomir Ghosh
- 申请人地址： US MA Cambridge
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D403/04 ; A61P29/00 ; A61P19/02 ; A61P11/00 ; A61P9/10 ; A61P3/10 ; A61P17/06 ; A61P1/00 ; A61P37/08 ; A61P11/06 ; A61P35/00 ; A61P19/08
摘要：
The present invention relates to compounds useful as Chemokine Receptor antagonists. Compounds of general formula I are provided: or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions for the inhibition of Chemokine Receptors and also for the treatment of various diseases, conditions, or disorders, including acute or chronic inflammatory disease, cancer or osteolytic bone disorders.
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