发明申请
- 专利标题： INHIBITION OF BRAIN ENZYMES INOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION
- 专利标题（中）： 脑损伤后脑组织中脑组织的抑制作用
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申请号： US13035658申请日： 2011-02-25
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公开(公告)号： US20110250260A1公开(公告)日： 2011-10-13
- 发明人: Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina
- 申请人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina
- 申请人地址： US CA Loma Linda US CA Los Angeles US NY Stony Brook US VA Arlington
- 专利权人： Loma Linda University Medical Center,The Regents of the University of California,The Research Foundation of State University of New York for and on behalf of State University of N.Y,George Mason University
- 当前专利权人： Loma Linda University Medical Center,The Regents of the University of California,The Research Foundation of State University of New York for and on behalf of State University of N.Y,George Mason University
- 当前专利权人地址： US CA Loma Linda US CA Los Angeles US NY Stony Brook US VA Arlington
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; A61P25/28 ; A61K9/127
摘要：
A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrinan in a manner that permits access to brain sites and/or the macula of the patient.
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