专利检索 ap:("Wolff Kirsch" OR "Lance A. Liotta" OR "William Van Nostrand" OR "Harry V. Vinters" OR "Virginia A. Espina") AND inv:"William Van Nostrand" 第 1 页

1.

发明申请
INHIBITION OF BRAIN ENZYMES INVOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION 审中-公开
标题翻译：参与谷氨酰胺转氨酶和谷氨酸降解的脑酶的抑制作用

公开(公告)号：US20090018094A1

公开(公告)日：2009-01-15

申请号：US11948856

申请日：2007-11-30

申请人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina

发明人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina

IPC分类号： A61K31/7105 , A61P25/28

CPC分类号： C12N15/1137 , A61K31/409 , C12N2310/14 , C12N2320/32 , C12Y114/99003

摘要： A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.

摘要翻译： 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括将含有siRNA的组合物给予血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂，胱天蛋白酶抑制剂或金属卟啉以允许接近患者的脑部位和/或黄斑的方式。

2.

发明申请
INHIBITION OF BRAIN ENZYMES INOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION 审中-公开
标题翻译：脑损伤后脑组织中脑组织的抑制作用

公开(公告)号：US20110250260A1

公开(公告)日：2011-10-13

申请号：US13035658

申请日：2011-02-25

申请人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina

发明人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina

IPC分类号： A61K31/713 , A61P25/28 , A61K9/127

CPC分类号： C12N15/1137 , A61K31/409 , C12N2310/14 , C12N2320/32 , C12Y114/99003

摘要： A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrinan in a manner that permits access to brain sites and/or the macula of the patient.

摘要翻译： 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括将含有siRNA的组合物给予血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂，胱天蛋白酶抑制剂或金属卟啉蛋白，其允许进入患者的脑部位和/或黄斑。

3.

发明申请
INHIBITION OF BRAIN ENZYMES INVOLVED IN CEREBRAL AMYLOID ANGIOPATHY AND MACULAR DEGENERATION 审中-公开
标题翻译：参与谷氨酰胺转氨酶和谷氨酸降解的脑酶的抑制作用

公开(公告)号：US20100047336A1

公开(公告)日：2010-02-25

申请号：US12542635

申请日：2009-08-17

申请人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina

发明人： Wolff Kirsch , Lance A. Liotta , William Van Nostrand , Harry V. Vinters , Virginia A. Espina

IPC分类号： A61K9/127 , A61K31/7052 , A61K31/555 , A61P25/28

CPC分类号： C12N15/1137 , A61K31/409 , C12N2310/14 , C12N2320/32 , C12Y114/99003

摘要： A method of treating or inhibiting progress of dementia and/or macular degeneration in a mammal involves administering compositions containing siRNA to heme oxygenase-1 (HO-1) or heme oxygenase-2 (HO-2), a matrix metalloproteinase (MMP) inhibitor, a caspase inhibitor, or a metalloporphyrin in a manner that permits access to brain sites and/or the macula of the patient.

摘要翻译： 治疗或抑制哺乳动物痴呆和/或黄斑变性进程的方法包括将含有siRNA的组合物给予血红素加氧酶-1（HO-1）或血红素加氧酶-2（HO-2），基质金属蛋白酶（MMP）抑制剂，胱天蛋白酶抑制剂或金属卟啉以允许接近患者的脑部位和/或黄斑的方式。