发明申请
US20110250653A1 L-SUCCINYLAMINOACYLASE AND PROCESS FOR PRODUCING L-AMINO ACID USING IT
有权
L-磺酰氨基酸和使用其生产L-氨基酸的方法
- 专利标题： L-SUCCINYLAMINOACYLASE AND PROCESS FOR PRODUCING L-AMINO ACID USING IT
- 专利标题（中）： L-磺酰氨基酸和使用其生产L-氨基酸的方法
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申请号： US13139205申请日： 2009-12-10
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公开(公告)号： US20110250653A1公开(公告)日： 2011-10-13
- 发明人: Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Shinya Kumagai
- 申请人： Atsushi Toda , Sachio Iwai , Yoshiaki Nishiya , Shinya Kumagai
- 申请人地址： JP Tokyo JP Osaka-shi, Osaka
- 专利权人： SEKISUI MEDICAL CO., LTD.,TOYO BOSEKI KABUSHIKI KAISHA
- 当前专利权人： SEKISUI MEDICAL CO., LTD.,TOYO BOSEKI KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo JP Osaka-shi, Osaka
- 优先权： JP2008-315233 20081211
- 国际申请： PCT/JP2009/006770 WO 20091210
- 主分类号： C12P13/04
- IPC分类号： C12P13/04 ; C12N15/55 ; C12N9/78
摘要：
The present invention provides a L-succinylacylase consisting of: (a) a protein coded by a gene consisting of a nucleic acid sequence shown in SEQ ID No: 1; (b) a protein consisting of an amino acid sequence shown in SEQ ID No: 2; (c) a protein coded by a polynucleotide which hybridizes under a stringent condition with a nucleic acid sequence which is complementary to the nucleic acid sequence shown in SEQ ID No: 1 and having an L-succinylaminoacylase activity; or (d) a protein which consists of an amino acid sequence where one or several amino acid(s) is/are substituted, deleted, inserted and/or added in the protein consisting of the amino acid sequence shown in SEQ ID No: 2 and has an L-succinylaminoacylase activity. This enzyme is able to produce a sterically bulky unnatural amino acid such as L-tert-leucine etc. which is useful as an intermediate for pharmaceuticals.
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