发明申请
US20110251085A1 IN VITRO METHOD TO DETERMINE WHETHER A DRUG CANDIDATE ACTIVE AGAINST A TARGET PROTEIN IS ACTIVE AGAINST A VARIANT OF SAID PROTEIN
审中-公开
用于确定与目标蛋白有关的药物候选药物的体外方法是否对一种不同的蛋白质有效
- 专利标题： IN VITRO METHOD TO DETERMINE WHETHER A DRUG CANDIDATE ACTIVE AGAINST A TARGET PROTEIN IS ACTIVE AGAINST A VARIANT OF SAID PROTEIN
- 专利标题（中）： 用于确定与目标蛋白有关的药物候选药物的体外方法是否对一种不同的蛋白质有效
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申请号： US12922409申请日： 2009-03-16
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公开(公告)号： US20110251085A1公开(公告)日： 2011-10-13
- 发明人: Mehdi Lahmar , Isabelle Valarche , Majid Mehtali
- 申请人： Mehdi Lahmar , Isabelle Valarche , Majid Mehtali
- 申请人地址： FR Roussay
- 专利权人： VIVALIS
- 当前专利权人： VIVALIS
- 当前专利权人地址： FR Roussay
- 优先权： EP08300146.1 20080314
- 国际申请： PCT/EP2009/053101 WO 20090316
- 主分类号： C40B30/04
- IPC分类号： C40B30/04
摘要：
The present invention relates to the field of virology. More precisely, the invention provides a method of determining the ability of a test compound to modulate the biological activity of a variant of a target protein, wherein said test compound is previously known to modulate the biological activity of said protein. This invention is useful to determine whether a drug candidate, such as anti-viral compounds (eg. against hepatitis C virus: NS5B, NS3), active against a target protein is active against a variant of said protein (eg. polymorphisms, genotypes or mutants).
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