发明申请
US20110251166A1 DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE BETA2 ADRENERGIC RECEPTOR
有权
4-(2-氨基-1-羟基乙基)苯酚的衍生物作为BETA2 ADRENERGIC受体的激动剂
- 专利标题: DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE BETA2 ADRENERGIC RECEPTOR
- 专利标题(中): 4-(2-氨基-1-羟基乙基)苯酚的衍生物作为BETA2 ADRENERGIC受体的激动剂
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申请号: US13094163申请日: 2011-04-26
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公开(公告)号: US20110251166A1公开(公告)日: 2011-10-13
- 发明人: Carlos PUIG DURAN , Maria Isabel Crespo Crespo , Julio Cesar Castro Palomino Laria , Silvia Gual Roig , Eloisa Navarro Romero
- 申请人: Carlos PUIG DURAN , Maria Isabel Crespo Crespo , Julio Cesar Castro Palomino Laria , Silvia Gual Roig , Eloisa Navarro Romero
- 优先权: ESP200501229 20050520
- 主分类号: A61K31/56
- IPC分类号: A61K31/56 ; A61K31/4704 ; A61K31/17 ; A61K31/4166 ; A61P29/00 ; A61P11/00 ; A61P15/06 ; A61P27/06 ; A61P25/00 ; A61P9/00 ; A61K31/138 ; A61K31/167
摘要:
The present invention provides a compound of formula (I) wherein: R1 is a group selected from —CH2OH, —NHC(O)H and R7 is a hydrogen atom; or R1 together with R2 form the group —NH—C(O)—CH═CH— wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon is atom in the phenyl ring holding R2; R3 is selected from hydrogen and halogen atoms or groups selected from —SO—R5, —SO2—R5, —NH—CO—NH2, —CO—NH2, hydantoino, C1-4alkyl, C1-4alkoxy and —SO2NR5R6; R4 is selected from hydrogen atoms, halogen atoms and C1-4alkyl groups; R5 is a C1-4alkyl group or C3-5 cycloalkyl; R6 is independently selected from hydrogen atoms and C1-4alkyl groups; n, p and q are independently 0, 1, 2, 3 or 4: m and s are independently 0, 1, 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13: the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.
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