发明申请
- 专利标题： Methods and Compositions for Reducing Amyloid Beta Levels
- 专利标题（中）： 降低淀粉样蛋白β水平的方法和组合
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申请号： US12826403申请日： 2010-06-29
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公开(公告)号： US20110256120A1公开(公告)日： 2011-10-20
- 发明人: Li Gan , Lennart Mucke , Erik Roberson , Sarah Mueller-Steiner
- 申请人： Li Gan , Lennart Mucke , Erik Roberson , Sarah Mueller-Steiner
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; C12N5/079 ; C12N9/64 ; A61P25/28 ; C12N15/63 ; C12N5/10 ; C12N1/00 ; C12N5/0793 ; C07H21/00
摘要：
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
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