发明申请
- 专利标题： Hepatitis B Virus Compositions and Methods of Use
- 专利标题（中）： 乙型肝炎病毒组合物和使用方法
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申请号： US12526759申请日： 2008-02-20
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公开(公告)号： US20110257080A1公开(公告)日： 2011-10-20
- 发明人: Ning Chai , John M. Taylor
- 申请人： Ning Chai , John M. Taylor
- 专利权人： Fox Chase Cancer Center
- 当前专利权人： Fox Chase Cancer Center
- 国际申请： PCT/US08/02236 WO 20080220
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C12N15/63 ; C12N15/867 ; A61P31/20 ; C07K16/08 ; A61K31/7088 ; C07H21/00 ; C12N7/00 ; C07K14/02
摘要：
A polypeptide comprising a preS1 region of hepatitis B virus (HBV), or a fragment thereof, and/or the preS2 region of HBV or a fragment thereof, and methods of use to inhibit virus infection are disclosed. A lentivirus comprising hepatitis B virus (HBV) envelope proteins, or a fragment thereof, and/or the L envelope protein of HBV and/or the M envelope protein of HBV or a fragment thereof, and/or the S envelope protein of HBV or a fragment thereof, and methods of use of this lentivirus HBV pseudovirus as a gene therapy to target hepatocytes for the administration of therapeutic agents are also disclosed.
公开/授权文献
- US08748373B2 Hepatitis B virus compositions and methods of use 公开/授权日：2014-06-10
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