发明申请
- 专利标题: ANTI-IL-12/IL-23 ANTIBODIES
- 专利标题(中): 抗IL-12 / IL-23抗体
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申请号: US13058914申请日: 2009-08-14
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公开(公告)号: US20110262445A1公开(公告)日: 2011-10-27
- 发明人: Adam William Clarke , Anthony Gerard Doyle , Philip Jennings , Lynn Dorothy Poulton , Bernadette Wai , Andrew James Pow
- 申请人: Adam William Clarke , Anthony Gerard Doyle , Philip Jennings , Lynn Dorothy Poulton , Bernadette Wai , Andrew James Pow
- 申请人地址: AU Macquarie Park
- 专利权人: CEPHALON AUSTRALIA PTY LTD.
- 当前专利权人: CEPHALON AUSTRALIA PTY LTD.
- 当前专利权人地址: AU Macquarie Park
- 优先权: AU2008904178 20080814
- 国际申请: PCT/AU2009/001047 WO 20090814
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K1/14 ; C07H21/00 ; C07H21/04 ; C07K1/107 ; C12P21/02 ; A61P19/02 ; A61P19/08 ; A61P11/00 ; A61P17/06 ; A61P25/00 ; A61P9/00 ; A61P29/00 ; A61P9/10 ; A61P17/14 ; A61P3/00 ; A61P25/28 ; A61P35/00 ; A61P37/08 ; A61P3/08 ; C07K16/24
摘要:
The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R β2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12Rβ1.
公开/授权文献
- US08563697B2 Anti-IL-12/IL-23 antibodies 公开/授权日:2013-10-22
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