发明申请
US20110263622A1 TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS
有权
四氢萘二酮和四氢环戊二烯作为PARP和TUBULIN聚合抑制剂
- 专利标题： TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS PARP AND TUBULIN POLYMERIZATION INHIBITORS
- 专利标题（中）： 四氢萘二酮和四氢环戊二烯作为PARP和TUBULIN聚合抑制剂
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申请号： US12934753申请日： 2009-03-26
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公开(公告)号： US20110263622A1公开(公告)日： 2011-10-27
- 发明人: Patrick René Angibaud , Laurence Anne Mevellec , Bruno Roux , Pierre-Henri Storck , Christophe Meyer , Jorge Eduardo Vialard
- 申请人： Patrick René Angibaud , Laurence Anne Mevellec , Bruno Roux , Pierre-Henri Storck , Christophe Meyer , Jorge Eduardo Vialard
- 申请人地址： BE ISSY-LES MOULINEAUX CEDEX 9 BE Beerse
- 专利权人： JANSSEN-CILAG,JANSSEN PHARMACEUTICA NV
- 当前专利权人： JANSSEN-CILAG,JANSSEN PHARMACEUTICA NV
- 当前专利权人地址： BE ISSY-LES MOULINEAUX CEDEX 9 BE Beerse
- 优先权： EP08153432.3 20080327
- 国际申请： PCT/EP2009/053598 WO 20090326
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61P35/00 ; C07D401/10 ; C07D221/12 ; A61K31/473
摘要：
The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.
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