发明申请
- 专利标题： REDUCING NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE AND EPOXYEICOSANOIDS
- 专利标题（中）： 减少可溶性环氧化物水解酶和环氧乙烷的抑制剂
-
申请号： US13100978申请日： 2011-05-04
-
公开(公告)号： US20110269831A1公开(公告)日： 2011-11-03
- 发明人: Bruce D. Hammock , Takaho Watanabe , Seung-Jin Ma , Susan E. Bennett , Judith S. Stern , Christophe Morisseau , In-Hae Kim
- 申请人： Bruce D. Hammock , Takaho Watanabe , Seung-Jin Ma , Susan E. Bennett , Judith S. Stern , Christophe Morisseau , In-Hae Kim
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 主分类号： A61K31/17
- IPC分类号： A61K31/17 ; A61K31/16 ; A61K31/27 ; A61P13/12 ; A61K31/336
摘要：
The invention provides uses and methods for reducing nephropathy in persons with diabetes mellitus (particularly Type 2 diabetes), in persons with metabolic syndrome, in persons with triglyceride levels over 215 mg/dL, and in persons with a cholesterol level over 200 mg/dL, by administering an inhibitor of soluble epoxide hydrolase (“sEH”). Optionally, a cis-epoxyeicosantrienoic acid (“EET”) can be administered with the sEH inhibitor. The invention further provides for using EETs in conjunction with one or more sEH inhibitors to reduce hypertension, and for compositions of EETs coated with a material insoluble in an acid of pH 3 but soluble in a solution with a pH of 7.4 or higher.
公开/授权文献
信息查询
