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    Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids
    1.
    发明授权
    Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids 有权
    用可溶性环氧化物水解酶和环氧类别的抑制剂减少肾病

    公开(公告)号：US08513302B2

    公开(公告)日：2013-08-20

    申请号：US13100978

    申请日：2011-05-04

    申请人： Bruce D. Hammock ,  Takaho Watanabe ,  Seung-Jin Ma ,  Susan E. Bennett ,  Judith S. Stern ,  Christophe Morisseau ,  In-Hae Kim

    发明人： Bruce D. Hammock ,  Takaho Watanabe ,  Seung-Jin Ma ,  Susan E. Bennett ,  Judith S. Stern ,  Christophe Morisseau ,  In-Hae Kim

    IPC分类号： A61K31/17 ,  A61K31/16

    CPC分类号： A61K31/70 ,  A61K31/17 ,  A61K31/355

    摘要： The invention provides uses and methods for reducing nephropathy in persons with diabetes mellitus (particularly Type 2 diabetes), in persons with metabolic syndrome, in persons with triglyceride levels over 215 mg/dL, and in persons with a cholesterol level over 200 mg/dL, by administering an inhibitor of soluble epoxide hydrolase (“sEH”). Optionally, a cis-epoxyeicosantrienoic acid (“EET”) can be administered with the sEH inhibitor. The invention further provides for using EETs in conjunction with one or more sEH inhibitors to reduce hypertension, and for compositions of EETs coated with a material insoluble in an acid of pH 3 but soluble in a solution with a pH of 7.4 or higher.

    摘要翻译： 本发明提供了在甘油三酯水平超过215mg / dL的人中以及胆固醇水平超过200mg / dL的人中减少糖尿病患者（特别是2型糖尿病）患有代谢综合征患者的肾病的用途和方法 ，通过施用可溶性环氧化物水解酶（“sEH”）的抑制剂。 任选地，顺式 - 环氧二十碳三烯酸（“EET”）可与sEH抑制剂一起施用。 本发明进一步提供使用EET与一种或多种sEH抑制剂联合以降低高血压，以及用不溶于pH 3但可溶于pH 7.4或更高的溶液的材料涂覆的EET组合物。

    Method for determining diet program effectiveness
    3.
    发明授权
    Method for determining diet program effectiveness 失效
    确定饮食计划有效性的方法

    公开(公告)号：US5639471A

    公开(公告)日：1997-06-17

    申请号：US469516

    申请日：1995-06-06

    申请人： Allen Chait ,  Dan Hatton ,  R. Brian Haynes ,  Chor San Heng Khoo ,  Penny Kris-Etherton ,  R. David C. Macnair ,  David McCarron ,  Jill Metz ,  Suzanne Oparil ,  Xavier Pi-Sunyer ,  Larry Resnick ,  Judith S. Stern ,  Paula J. Ziegler

    发明人： Allen Chait ,  Dan Hatton ,  R. Brian Haynes ,  Chor San Heng Khoo ,  Penny Kris-Etherton ,  R. David C. Macnair ,  David McCarron ,  Jill Metz ,  Suzanne Oparil ,  Xavier Pi-Sunyer ,  Larry Resnick ,  Judith S. Stern ,  Paula J. Ziegler

    IPC分类号： A23L33/00 ,  A61B5/00 ,  A61B5/20 ,  A61K47/00

    CPC分类号： A61B5/14507 ,  A23L33/30 ,  A61B5/00 ,  A61B5/20

    摘要： The invention is a method for determining the effectiveness of a diet program for administration to a patient having at least one diet-responsive condition. The method includes the steps of selecting a plurality of patients, each having at least one diet-responsive condition; identifying at least one quantifiable indicator of each of the diet-responsive conditions and measuring the at least one indicator for each of the patient during a four week baseline period; and monitoring each of the patients during the baseline period to determine a baseline quality of life. The plurality of patient are divided randomly between a first group and a second group. The diet program is administered to each of the patients in the first group during a ten week intervention period and each of the patient in the second group is maintained on a control diet with known beneficial effects on the at least one diet-responsive condition during the intervention period. The at least one indicator of each of the conditions is monitored for each of the patient after the intervention period.

    摘要翻译： 本发明是一种用于确定用于给予具有至少一种饮食反应状况的患者的饮食程序的有效性的方法。 该方法包括以下步骤：选择多个患者，每个患者具有至少一种饮食反应状态; 识别每个饮食反应性条件的至少一个可量化指标，并在四周的基准期内测量每个患者的至少一个指标; 并在基线期间监测每个患者以确定基线生活质量。 多个患者在第一组和第二组之间随机分配。 在10周的干预期内，对第一组中的每个患者施用饮食程序，并且在第二组中的每个患者在第二组的每一个患者中维持对具有已知有益效果的对照饮食，所述对照饮食在所述至少一种饮食反应状态期间 干预期 在干预期之后，监测每个患者的每个病况的至少一个指标。