发明申请
US20110275119A1 METHODS FOR RIBOSOMAL SYNTHESIS OF POLYPEPTIDES CONTAINING UNNATURAL N-TERMINAL GROUPS AND APPLICATIONS THEREOF
有权
含有未知N末端组的多肽的RIBOSOMAL合成方法及其应用
- 专利标题： METHODS FOR RIBOSOMAL SYNTHESIS OF POLYPEPTIDES CONTAINING UNNATURAL N-TERMINAL GROUPS AND APPLICATIONS THEREOF
- 专利标题（中）： 含有未知N末端组的多肽的RIBOSOMAL合成方法及其应用
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申请号： US12515074申请日： 2007-11-13
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公开(公告)号： US20110275119A1公开(公告)日： 2011-11-10
- 发明人: Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Atsushi Ohta
- 申请人： Hiroaki Suga , Hiroshi Murakami , Yuki Goto , Atsushi Ohta
- 优先权： JP2006-312000 20061117
- 国际申请： PCT/JP2007/071986 WO 20071113
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N9/10
摘要：
The present invention aims to synthesize a polypeptide having an unnatural structure at the N-terminus via a biosynthetic process by translation of amino acid sequence information encoded by a nucleic acid. A polypeptide having any amino acid at the N-terminus is synthesized by using an ARS ribozyme that catalyzes the acylation of tRNA with any amino acid to attach any amino acid to an initiator tRNA, thereby initiating a translation with the initiator tRNA.