发明申请
US20110275595A1 Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
有权
取代的正丙胺的脲衍生物，含有这些化合物的药物及其用途
- 专利标题： Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use
- 专利标题（中）： 取代的正丙胺的脲衍生物，含有这些化合物的药物及其用途
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申请号： US13124259申请日： 2009-10-22
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公开(公告)号： US20110275595A1公开(公告)日： 2011-11-10
- 发明人: Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach
- 申请人： Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP08167440.0 20081023
- 国际申请： PCT/EP09/63913 WO 20091022
- 主分类号： A61K31/695
- IPC分类号： A61K31/695 ; A61K31/501 ; A61K31/46 ; C07D451/02 ; C07F7/02 ; A61P3/00 ; A61P3/10 ; A61K31/5377 ; A61P3/04
摘要：
The present invention relates to compounds defined by formula I wherein the groups R1, Y1 to Y4, V, W, and X are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
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