发明申请
US20110280861A1 METHOD FOR MIR-125A IN PROMOTING HEMATOPOIETIC STEM CELL SELF RENEWAL AND EXPANSION
审中-公开
MIR-125A在促进HEMATOPOIETIC干细胞自我更新和扩张的方法
- 专利标题： METHOD FOR MIR-125A IN PROMOTING HEMATOPOIETIC STEM CELL SELF RENEWAL AND EXPANSION
- 专利标题（中）： MIR-125A在促进HEMATOPOIETIC干细胞自我更新和扩张的方法
-
申请号： US13058076申请日： 2009-08-10
-
公开(公告)号： US20110280861A1公开(公告)日： 2011-11-17
- 发明人: David Scadden , Shangqin Guo , Jun Lu
- 申请人： David Scadden , Shangqin Guo , Jun Lu
- 申请人地址： US MA Cambridge US MA Boston
- 专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY,THE GENERAL HOSPITAL CORPORATION
- 当前专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY,THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址： US MA Cambridge US MA Boston
- 国际申请： PCT/US09/53290 WO 20090810
- 主分类号： A61K31/7105
- IPC分类号： A61K31/7105 ; A61K31/7088 ; A61K39/395 ; A61P35/02 ; A61K35/12 ; A61P37/02 ; A61P35/00 ; C12N5/0789 ; A61K38/02
摘要：
Embodiments of the invention relate to methods and compositions for the expansion of hematopoietic stem cell (HSC) self renewal. The microRNA-125a is a master control of HSC self-renewal. Increased expression of mir-125a increased HSC self-renewal by 6-30 folds. Increased expression of mir-125a can be used to expand HSC ex vivo and in vivo.
信息查询
IPC分类:
