发明申请
- 专利标题： Oligoribonucleotide or Peptide Nucleic Acid Capable of Inhibiting Activity of Hepatitis C Virus
- 专利标题（中）： 能够抑制丙型肝炎病毒活性的寡核苷酸或肽核酸
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申请号： US13130673申请日： 2009-11-26
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公开(公告)号： US20110281271A1公开(公告)日： 2011-11-17
- 发明人: Michinori Kohara , Masayuki Sudo
- 申请人： Michinori Kohara , Masayuki Sudo
- 申请人地址： JP Tokyo JP Tokyo
- 专利权人： TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE,CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人： TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE,CHUGAI SEIYAKU KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo JP Tokyo
- 优先权： JP2008-301764 20081126
- 国际申请： PCT/JP2009/069934 WO 20091126
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/02 ; C07H21/04 ; C12N5/071
摘要：
The present inventors focused on siE sequences that have been thought to show RNAi activity against HCV viral RNAs, and mainly selected the D5-50 and D5-197 regions present within the IRES region, and carried on the analysis. As a result, the present inventors successfully identified siRNA sequences that exhibit a more effective RNAi activity against hepatitis C virus RNAs. Furthermore, the siRNAs were demonstrated to have a significant inhibitory effect on HCV propagation in an in vivo system.
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