发明申请
US20110281908A1 Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
审中-公开
氨基喹啉衍生的热休克蛋白90抑制剂，制备方法及其使用方法
- 专利标题： Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
- 专利标题（中）： 氨基喹啉衍生的热休克蛋白90抑制剂，制备方法及其使用方法
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申请号： US13122785申请日： 2009-10-06
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公开(公告)号： US20110281908A1公开(公告)日： 2011-11-17
- 发明人: Aiming Sun , Ganesh Thota , Jaeki Min , Pahk Thepchatri , Yuhong Du , James P Snyder , Dennis C. Liotta
- 申请人： Aiming Sun , Ganesh Thota , Jaeki Min , Pahk Thepchatri , Yuhong Du , James P Snyder , Dennis C. Liotta
- 申请人地址： US GA Atlanta
- 专利权人： EMORY UNIVERSITY
- 当前专利权人： EMORY UNIVERSITY
- 当前专利权人地址： US GA Atlanta
- 国际申请： PCT/US09/59658 WO 20091006
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/4709 ; C07D401/12 ; C07D215/38 ; A61P35/00
摘要：
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.
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