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    COMPOSITIONS AND METHODS FOR IMPROVING EMBRYO DEVELOPMENT
    3.
    发明公开
    COMPOSITIONS AND METHODS FOR IMPROVING EMBRYO DEVELOPMENT 审中-公开

    公开(公告)号：US20240301349A1

    公开(公告)日：2024-09-12

    申请号：US18440821

    申请日：2024-02-13

    申请人： University of Georgia Research Foundation, Inc. ,  Emory University

    发明人： Charles A. Easley, IV ,  Anthony W.S. Chan

    IPC分类号： C12N5/073 ,  C12N5/076 ,  C12N15/90

    CPC分类号： C12N5/0604 ,  C12N5/061 ,  C12N15/90 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2517/10

    摘要： Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.

    NOVEL UNIVERSAL ANTI-RNA VIRUS AGENTS
    5.
    发明公开
    NOVEL UNIVERSAL ANTI-RNA VIRUS AGENTS 审中-公开

    公开(公告)号：US20240262857A1

    公开(公告)日：2024-08-08

    申请号：US18562911

    申请日：2022-05-27

    申请人： Emory University

    发明人： Raymond F. Schinazi ,  Frank Amblard

    IPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K45/06 ,  A61P31/14 ,  C07B59/00

    CPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K45/06 ,  A61P31/14 ,  C07B59/002 ,  C07B2200/05

    摘要： Deuterated and/or methylated N4-hydroxycytidine (NHC) analogs, with deuteration at one or both of the 2′- and 3′-positions on the ribo-sugar moiety and/or methylation of the 3′-positions on the ribo-sugar moiety, pharmaceutical compositions comprising one or more of these compounds, and, optionally, at least one additional therapeutic agent, and methods of treating or preventing infections caused by RNA viruses, curing an infection by an RNA virus, or reducing the biological activity of an RNA virus, are disclosed. Representative RNA viruses include, but are not limited to, Coronaviridae, such as MERSr-CoV, SARS-CoV-1, SARSCoV-2, HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1, Picornaviridae, Hepeviridae, Noroviruses, Zika, Dengue, Mayaro, Influenza A and B, Parainfluenza, HCV, Rinovirus, tick-borne viruses, Ebola, Lassa, RSV, adenoviruses, enteroviruses, metapneumoviruses, Eastern, Western, and Venezuelan Equine Encephalitis (EEE, WEE and VEE, respectively), and Chikungunya fever (CHIK).