发明申请
- 专利标题： FVIII Muteins for Treatment of Von Willebrand Disease
- 专利标题（中）： FVIII突变蛋白治疗血管性血友病
-
申请号： US12996629申请日： 2009-06-04
-
公开(公告)号： US20110286988A1公开(公告)日： 2011-11-24
- 发明人: Haiyan Jiang , Glenn Pierce , John E. Murphy , Junliang Pan , Xin Zhang , Tongyao Liu
- 申请人： Haiyan Jiang , Glenn Pierce , John E. Murphy , Junliang Pan , Xin Zhang , Tongyao Liu
- 申请人地址： US NY Tarrytown
- 专利权人： BAYER HEALTHCARE LLC
- 当前专利权人： BAYER HEALTHCARE LLC
- 当前专利权人地址： US NY Tarrytown
- 国际申请： PCT/US09/46327 WO 20090604
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; A61P7/00 ; A61P7/04 ; C12N9/96
摘要：
This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.
信息查询
IPC分类:
