公开(公告)号：US20110286988A1

公开(公告)日：2011-11-24

申请号：US12996629

申请日：2009-06-04

申请人： Haiyan Jiang ,  Glenn Pierce ,  John E. Murphy ,  Junliang Pan ,  Xin Zhang ,  Tongyao Liu

发明人： Haiyan Jiang ,  Glenn Pierce ,  John E. Murphy ,  Junliang Pan ,  Xin Zhang ,  Tongyao Liu

IPC分类号： A61K38/48 ,  A61P7/00 ,  A61P7/04 ,  C12N9/96

CPC分类号： A61K38/37

摘要： This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.

摘要翻译： 本发明涉及通过施用在一个或多个生物相容性聚合物如聚乙二醇上共价结合的不是N-末端胺的预定位点的因子VIII突变蛋白来治疗血管性血友病。 突变蛋白偶联物保留FVIII促凝血活性，并且在缺乏血管性血友病因子的受试者中具有改善的药代动力学性质。

公开(公告)号：US20110077202A1

公开(公告)日：2011-03-31

申请号：US12992879

申请日：2009-05-15

申请人： Richard Feldman ,  Ji-Yun Kim ,  Haiyan Jiang ,  Kirk Mclean ,  Junliang Pan ,  Glenn Pierce ,  James Wu ,  Xiao-Yan Zhao

发明人： Richard Feldman ,  Ji-Yun Kim ,  Haiyan Jiang ,  Kirk Mclean ,  Junliang Pan ,  Glenn Pierce ,  James Wu ,  Xiao-Yan Zhao

IPC分类号： A61K38/36 ,  C07K14/745 ,  C07K14/755 ,  A61P7/00

CPC分类号： C07K14/755 ,  A61K38/00 ,  A61K38/37 ,  A61K38/4846 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6849 ,  C07K16/2839 ,  C07K16/2848 ,  C07K2317/622 ,  C07K2319/30 ,  C07K2319/33

摘要： Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

摘要翻译： 提供了包含与至少一个与血细胞上的膜蛋白特异性结合的结构域连接的凝血因子的靶向凝血因子。 所公开的靶向凝血因子增加凝血因子的效率并延长其作用时间，因此是治疗血液病如血友病A的改善。

公开(公告)号：US20120269817A1

公开(公告)日：2012-10-25

申请号：US13057728

申请日：2009-08-04

申请人： Zhuozhi Wang ,  John E. Murphy ,  Junliang Pan ,  Haiyan Jiang ,  Bing Liu

发明人： Zhuozhi Wang ,  John E. Murphy ,  Junliang Pan ,  Haiyan Jiang ,  Bing Liu

IPC分类号： A61K39/395 ,  C12P21/08 ,  C12N15/13 ,  C07K16/18 ,  A61P7/04

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体和编码它们的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。

公开(公告)号：US08481030B2

公开(公告)日：2013-07-09

申请号：US13323691

申请日：2011-12-12

申请人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： A61K39/395

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体。 还考虑了编码结合TFPI的单克隆抗体的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。

公开(公告)号：US20120108796A1

公开(公告)日：2012-05-03

申请号：US13323691

申请日：2011-12-12

申请人： Zhuozhi WANG ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi WANG ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： C07K16/18

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

公开(公告)号：US5605821A

公开(公告)日：1997-02-25

申请号：US110158

申请日：1993-08-20

申请人： Rodger P. McEver ,  Junliang Pan

发明人： Rodger P. McEver ,  Junliang Pan

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61P9/00 ,  A61P11/00 ,  A61P37/00 ,  C07K1/22 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/28 ,  C07K19/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/85 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/577 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/70596 ,  C07K14/70564 ,  C07K16/2854 ,  C12N15/85 ,  A61K38/00 ,  C12N2830/002 ,  C12N2830/008 ,  C12N2830/85

摘要： DNA molecules and methods for the regulated expression of a gene in endothelial cells or megakaryocytes, are described, wherein the 5' flanking region of the P-selectin gene, or portions thereof, is ligated to the 5' end of a gene. The DNA molecules are also used as probes for screening individuals with abnormal levels of expression of P-selectin, or for production of pharmaceutical compositions to inhibit inflammation by inhibition of expression of P-selectin. These DNA molecules can also be used to identify and isolate previously unknown proteins which are involved in regulation of gene expression.

摘要翻译： 描述了用于在内皮细胞或巨核细胞中调节基因表达的DNA分子和方法，其中P-选择蛋白基因的5'侧翼区或其部分连接到基因的5'末端。 DNA分子也用作筛选具有异常选择蛋白表达水平异常的个体的探针，或用于通过抑制P-选择蛋白的表达产生抑制炎症的药物组合物的探针。 这些DNA分子也可用于鉴定和分离参与调控基因表达的先前未知的蛋白质。

公开(公告)号：US09309324B2

公开(公告)日：2016-04-12

申请号：US13582401

申请日：2011-03-01

申请人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： A61K39/395 ,  C07K16/38 ,  A61K39/00

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

公开(公告)号：US20120329996A1

公开(公告)日：2012-12-27

申请号：US13582401

申请日：2011-03-01

申请人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

发明人： Zhuozhi Wang ,  Junliang Pan ,  Joanna Grudzinska ,  Christian Votsmeier ,  Jan Tebbe ,  Joerg Birkenfeld ,  Nina Wobst ,  Simone Brueckner ,  Susanne Steinig ,  Peter Scholz

IPC分类号： C07K16/18

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体。 还考虑了编码结合TFPI的单克隆抗体的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。

公开(公告)号：US20090286721A1

公开(公告)日：2009-11-19

申请号：US11817454

申请日：2005-09-06

申请人： Junliang Pan ,  Qingyu Wu ,  Achim Schuttler ,  Annemarie Schuttler

发明人： Junliang Pan ,  Qingyu Wu ,  Achim Schuttler ,  Annemarie Schuttler

IPC分类号： A61K38/00 ,  C07K19/00 ,  C07K16/00 ,  A61P7/00 ,  A61P9/00 ,  C07H21/04 ,  A61K48/00

CPC分类号： C12N9/6456 ,  A61K38/00 ,  A61K47/6849 ,  C07K2319/33

摘要： This invention relates to novel fusion proteins, comprising a targeting protein and a plasminogen activator, preferably an antibody that binds to P-selectin, operably linked to the plasminogen activator DSPAalpha1, or analogs, fragments, derivatives, or variants thereof, which are useful as thrombolytic agents. Pharmaceutical compositions containing these fusion proteins, methods of using these fusion proteins as thrombolytic agents, and processes for synthesizing these fusion proteins are also described herein.

摘要翻译： 本发明涉及新颖的融合蛋白，其包含靶向蛋白和纤溶酶原激活剂，优选结合P-选择素的抗体，其可操作地连接于纤溶酶原激活物DSPAalpha1或其类似物，片段，衍生物或变体，其可用作 溶栓剂。 包含这些融合蛋白的药物组合物，使用这些融合蛋白作为溶栓剂的方法，以及合成这些融合蛋白的方法也在本文中描述。

公开(公告)号：US06692922B2

公开(公告)日：2004-02-17

申请号：US09931381

申请日：2001-08-15

申请人： Eugene C. Butcher ,  Eric J. Kunkel ,  Junliang Pan ,  Dulce Soler-Ferrán

发明人： Eugene C. Butcher ,  Eric J. Kunkel ,  Junliang Pan ,  Dulce Soler-Ferrán

IPC分类号： G01N3353

CPC分类号： G01N33/6863 ,  A61K2039/505 ,  C07K14/523

摘要： The invention relates to the interaction of MEC with CCR3 and/or CCR10 and to agents (e.g., ligands, antibodies, antagonists, agonists, inhibitors, promoters) which alter said interaction. In one aspect, the invention relates to methods for detecting or identifying an agent (i.e., molecule or compound) which can modulate (inhibit, promote) the binding of MEC to CCR3 and/or CCR10. In another aspect, the invention relates to a method of treating a subject having an inflammatory condition, comprising administering to the subject an effective amount of an agent which modulates the binding of MEC to CCR3 and/or CCR10.

摘要翻译： 本发明涉及MEC与CCR3和/或CCR10的相互作用以及改变所述相互作用的试剂（例如配体，抗体，拮抗剂，激动剂，抑制剂，启动子）。 一方面，本发明涉及用于检测或鉴定可以调节（抑制，促进）MEC与CCR3和/或CCR10的结合的试剂（即分子或化合物）的方法。 另一方面，本发明涉及治疗患有炎性病症的受试者的方法，其包括向所述受试者施用有效量的调节MEC与CCR3和/或CCR10结合的药剂。