发明申请
- 专利标题： Yeast Screens for Treatment of Human Disease
- 专利标题（中）： 用于治疗人类疾病的酵母筛
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申请号： US13090653申请日： 2011-04-20
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公开(公告)号： US20110300533A1公开(公告)日： 2011-12-08
- 发明人: Susan Lindquist , Sylvia Krobitsch , Tiago Fleming Outeiro
- 申请人： Susan Lindquist , Sylvia Krobitsch , Tiago Fleming Outeiro
- 专利权人： The University of Chicago
- 当前专利权人： The University of Chicago
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/02
摘要：
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
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