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公开(公告)号：US20130005608A1
公开(公告)日：2013-01-03
申请号：US13462478
申请日：2012-05-02
CPC分类号： C12Q1/18 , C12Q1/02 , C12Q1/025 , G01N33/6896 , G01N2333/4703 , G01N2500/00 , G01N2800/2835
摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
摘要翻译： 提供了用于鉴定为与蛋白质错折叠相关的各种疾病提供治疗价值的物质的筛选方法。 使用酵母系统提供遗传和化学筛选方法。 本发明的方法提供了一种快速和具有成本效益的方法来筛选防止蛋白质错折叠和/或蛋白质原纤维形成和/或蛋白质聚集的化合物，其包括许多神经变性疾病，包括帕金森病，阿尔茨海默氏病，亨廷顿氏病以及非 - - 神经性疾病如2型糖尿病。
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公开(公告)号：US08039209B2
公开(公告)日：2011-10-18
申请号：US11363870
申请日：2006-02-27
IPC分类号： C12Q1/68
CPC分类号： C12Q1/18 , C12Q1/02 , C12Q1/025 , G01N33/6896 , G01N2333/4703 , G01N2500/00 , G01N2800/2835
摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
摘要翻译： 提供了用于鉴定为与蛋白质错折叠相关的各种疾病提供治疗价值的物质的筛选方法。 使用酵母系统提供遗传和化学筛选方法。 本发明的方法提供了一种快速和具有成本效益的方法来筛选防止蛋白质错折叠和/或蛋白质原纤维形成和/或蛋白质聚集的化合物，其包括许多神经变性疾病，包括帕金森病，阿尔茨海默氏病，亨廷顿氏病以及非 - - 神经性疾病如2型糖尿病。
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公开(公告)号：US20110300533A1
公开(公告)日：2011-12-08
申请号：US13090653
申请日：2011-04-20
CPC分类号： C12Q1/18 , C12Q1/02 , C12Q1/025 , G01N33/6896 , G01N2333/4703 , G01N2500/00 , G01N2800/2835
摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
摘要翻译： 提供了用于鉴定为与蛋白质错折叠相关的各种疾病提供治疗价值的物质的筛选方法。 使用酵母系统提供遗传和化学筛选方法。 本发明的方法提供了一种快速和具有成本效益的方法来筛选防止蛋白质错折叠和/或蛋白质原纤维形成和/或蛋白质聚集的化合物，其包括许多神经变性疾病，包括帕金森病，阿尔茨海默氏病，亨廷顿氏病以及非 - - 神经性疾病如2型糖尿病。
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公开(公告)号：US07045290B2
公开(公告)日：2006-05-16
申请号：US10077584
申请日：2002-02-15
IPC分类号： C12Q1/68
CPC分类号： C12Q1/18 , C12Q1/02 , C12Q1/025 , G01N33/6896 , G01N2333/4703 , G01N2500/00 , G01N2800/2835
摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
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公开(公告)号：US20060141449A1
公开(公告)日：2006-06-29
申请号：US11363870
申请日：2006-02-27
申请人： Susan Lindquist , Sylvia Krobitsch , Tiago Outeiro
发明人： Susan Lindquist , Sylvia Krobitsch , Tiago Outeiro
CPC分类号： C12Q1/18 , C12Q1/02 , C12Q1/025 , G01N33/6896 , G01N2333/4703 , G01N2500/00 , G01N2800/2835
摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
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公开(公告)号：US20060147902A1
公开(公告)日：2006-07-06
申请号：US11363869
申请日：2006-02-27
申请人： Susan Lindquist , Sylvia Krobitsch , Tiago Outeiro
发明人： Susan Lindquist , Sylvia Krobitsch , Tiago Outeiro
CPC分类号： C12Q1/18 , C12Q1/02 , C12Q1/025 , G01N33/6896 , G01N2333/4703 , G01N2500/00 , G01N2800/2835
摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.
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