发明申请
- 专利标题： NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITONS
- 专利标题（中）： 抗微生物，抗细菌免疫组织化学
-
申请号： US13156677申请日： 2011-06-09
-
公开(公告)号： US20110305872A1公开(公告)日： 2011-12-15
- 发明人: Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
- 申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
- 主分类号： B32B3/00
- IPC分类号： B32B3/00 ; D03D15/00 ; D04H13/00 ; B05D3/10
摘要：
A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.