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1.发明授权Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties 有权具有非污垢表面的制品及其制备方法，而不改变体积物理性能公开(公告)号：US08574660B2
公开(公告)日：2013-11-05
申请号：US13156904
申请日：2011-06-09
申请人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： A61L33/00
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
摘要翻译： 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 这些方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理特性，然后在经处理的基材表面上形成接枝聚合物层。
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公开(公告)号：US20110305872A1
公开(公告)日：2011-12-15
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译： 一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有 在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟 。
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3.发明授权公开(公告)号：US09096703B2
公开(公告)日：2015-08-04
申请号：US13156677
申请日：2011-06-09
申请人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Jun Li , Zheng Zhang , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： C08F255/02 , A61L29/06 , A61L29/08 , A61L33/00 , C08F291/00 , C08J7/16 , C08J7/18 , C08G18/83 , C08G64/42 , C08G77/38
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
摘要翻译： 一种用于制备和产生的制品的方法，包括具有表面，表面下面的体积的基材和在基材表面上的接枝聚合物层，基底表面和接枝聚合物层的组合，构成具有 在纤维蛋白原结合测定中纤维蛋白原吸附量小于约125ng / cm 2，其中将修饰的表面在37℃下在70μg/ mL来自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟 。
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4.发明申请公开(公告)号：US20110305909A1
公开(公告)日：2011-12-15
申请号：US13156904
申请日：2011-06-09
申请人： Douglas J.K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Douglas J.K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
摘要翻译： 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 这些方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理特性，然后在经处理的基材表面上形成接枝的聚合物层。
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公开(公告)号：US20110305898A1
公开(公告)日：2011-12-15
申请号：US13156708
申请日：2011-06-09
申请人： Zheng Zhang , Jun Li , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Zheng Zhang , Jun Li , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： B32B3/00 , B32B9/04 , B32B27/40 , B32B27/00 , B32B17/06 , D04H13/00 , D03D15/00 , A61L33/00 , B32B15/04
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
摘要翻译： 本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。 表面抗生物材料的粘附。
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公开(公告)号：US08308699B2
公开(公告)日：2012-11-13
申请号：US12632669
申请日：2009-12-07
申请人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
发明人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
IPC分类号： A61M25/00 , C08F290/14 , C08F112/08 , C08F283/04 , C08F120/10 , C08F20/56 , C08F283/02 , C08G77/38
CPC分类号： A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
摘要： Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
摘要翻译： 本文描述了任选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。 非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。 本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。 本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。 可以将非结垢材料接枝到官能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能。
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公开(公告)号：US20100152708A1
公开(公告)日：2010-06-17
申请号：US12632686
申请日：2009-12-07
申请人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
发明人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
IPC分类号： A61L29/14 , C08F290/14 , B32B5/02 , B32B15/08 , B32B27/04 , B32B27/36 , B32B9/04 , B32B27/38 , C08F112/08 , C08F283/04 , C08F283/06 , C08F283/12 , C08F220/56 , C08F210/00 , C07H1/00 , C07H23/00 , C08J3/28 , B05D3/06
CPC分类号： A61L33/06 , A61L27/14 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C08L25/08 , C08L75/04 , C09D5/1637 , C09D5/1693 , C09D151/003 , C09D151/06 , C09D151/08 , C09D151/085 , C08F220/38 , C08F220/56 , C08L2666/02
摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
摘要翻译： 本文描述了任选地涂覆有底涂层的底物，其从一种或多种非结垢材料接枝到其上。 不污染的聚合物材料可以从各种基材，特别是聚合物基材和/或聚合物底涂层移植。 本文所述的接枝技术可以导致非污染材料相对于接枝与制剂的更高的表面密度。 可以使用接枝方法制备共价连接的聚合物。 本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。 本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。 非污染材料可以从衬底或任选地从衬底上的底涂层移植，优选不显着影响衬底材料的机械和/或物理性能。
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公开(公告)号：US20100145286A1
公开(公告)日：2010-06-10
申请号：US12632669
申请日：2009-12-07
申请人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
发明人： Zheng Zhang , Chad Huval , William Shannan O'Shaughnessey , Michael Hencke , Trevor Squier , Jun Li , Michael Bouchard , Christopher R. Loose
IPC分类号： A61M25/00 , C08F290/14 , C08F112/08 , C08F283/04 , C08F120/10 , C08F20/56 , C08F283/02 , C08G77/38 , B32B27/04 , C08G59/14 , C08G69/48 , C08F10/00 , C08G75/00 , C08F20/44 , C07H1/00 , B32B27/36 , B32B27/34 , B32B27/38
CPC分类号： A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
摘要： Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material
摘要翻译： 本文描述了任选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。 非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。 本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。 本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。 非结垢材料可以接枝到功能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能
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公开(公告)号：US09895470B2
公开(公告)日：2018-02-20
申请号：US12632686
申请日：2009-12-07
申请人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
发明人： Jun Li , Trevor Squier , Zheng Zhang , Chad Huval , William Shannan O'Shaughnessy , Michael Hencke , Michael Bouchard , Christopher R. Loose
IPC分类号： A61L33/06 , A61L27/34 , A61L27/50 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , C07H23/00 , C09D5/16 , C09D151/00 , C09D151/06 , C09D151/08 , C08L75/04 , C08L25/08
CPC分类号： A61L33/06 , A61L27/14 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C08L25/08 , C08L75/04 , C09D5/1637 , C09D5/1693 , C09D151/003 , C09D151/06 , C09D151/08 , C09D151/085 , C08F220/38 , C08F220/56 , C08L2666/02
摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
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