发明申请
US20110306638A1 BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE
审中-公开
苯并噻唑苯哌啶衍生物，包含衍生物及其用途的药物组合物
- 专利标题： BENZISOXAZOLE PIPERIDINYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE DERIVATIVES AND THEIR USE
- 专利标题（中）： 苯并噻唑苯哌啶衍生物，包含衍生物及其用途的药物组合物
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申请号： US13141811申请日： 2009-12-22
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公开(公告)号： US20110306638A1公开(公告)日： 2011-12-15
- 发明人: Jianqi Li , Guan Wang , Guisen Zhang , Na Lv , Guangjun Jiao , Shicheng Liu , Shixia Zhou
- 申请人： Jianqi Li , Guan Wang , Guisen Zhang , Na Lv , Guangjun Jiao , Shicheng Liu , Shixia Zhou
- 申请人地址： CN Xuzhou City
- 专利权人： NHWA PHARMA. CORPORATION
- 当前专利权人： NHWA PHARMA. CORPORATION
- 当前专利权人地址： CN Xuzhou City
- 优先权： CN200810207606.7 20081223
- 国际申请： PCT/CN09/75842 WO 20091222
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; A61P25/20 ; A61P25/04 ; C07D413/14 ; A61P29/00
摘要：
The invention relates to a benzisoxazolyl piperidine derivative having the following general formula, a salt or a hydrate thereof, wherein R, X, Y, R′ and T are defined as in the specification. Such compounds have serotonin system modulating effects such as antagonizing effect on 5-HT2A and inhibitory effect on 5-HT reuptake. The compounds have good analgesic and sedative activities with mild toxic and side effects. The invention also relates to a composition comprising said derivative and the use thereof.
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