发明申请
US20110311569A1 HIV-1 Peptides, Nucleic Acids, and Compositions and Uses Thereof
审中-公开
HIV-1肽，核酸及其组合物及用途
- 专利标题： HIV-1 Peptides, Nucleic Acids, and Compositions and Uses Thereof
- 专利标题（中）： HIV-1肽，核酸及其组合物及用途
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申请号： US12309256申请日： 2007-07-10
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公开(公告)号： US20110311569A1公开(公告)日： 2011-12-22
- 发明人: Abraham Pinter
- 申请人： Abraham Pinter
- 国际申请： PCT/US2007/015703 WO 20070710
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C07K7/06 ; C07K9/00 ; A61P31/18 ; C12N15/49 ; C12N15/63 ; C12N7/06 ; A61P37/04 ; C07K14/16 ; C07K16/10
摘要：
This invention features polypeptides, variants thereof, and fragments thereof useful in eliciting an immune response (e.g., neutralizing antibodies) against abroad spectrum of HIV-I isolates. The polypeptides, variants, and fragments include a portion of the gp120 V2 domain of HIV-I. The polypeptides, variants, and fragments display an epitope that is recognized by at least one antibody which neutralizes at least one HIV-I primary isolate. This invention also features nucleic acid sequences encoding those polypeptides. In addition, the invention provides methods of screening for inhibitors of HIV-I entry into cells, as well as methods of treatment using the inhibitors.